{"id":13093,"date":"2026-02-17T10:00:11","date_gmt":"2026-02-17T09:00:11","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=13093"},"modified":"2026-02-16T16:28:32","modified_gmt":"2026-02-16T15:28:32","slug":"snapshot-of-the-month-topography-of-the-living","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/en\/snapshot-of-the-month-topography-of-the-living\/","title":{"rendered":"Snapshot of the month: \u201cTopography of the Living\u201d"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-13108\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-scaled.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-scaled.jpg 2560w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">If we could perceive it, <\/span><b>what sound would ageing make?<\/b><span style=\"font-weight: 400;\"> What notes would represent the changes in shape, structure and colour that occur over the years? And, conversely, what signals would our body emit if it were capable of reversing that process?<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Perhaps such a sound exists but we&#8217;re simply not capable of hearing it. Something similar occurs in our latest <\/span><i><span style=\"font-weight: 400;\">Snapshot of the Month<\/span><\/i><span style=\"font-weight: 400;\">. As if we were experiencing <\/span><a href=\"https:\/\/www.quironsalud.com\/blogs\/es\/neuropediatra\/sinestesia-fenomeno-neurologico-arte-ciencia-i-parte\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">sensory synaesthesia<\/span><\/a><span style=\"font-weight: 400;\">, the scientific image in question <\/span><b>awakens seemingly unconnected or even contradictory sensations<\/b><span style=\"font-weight: 400;\">: a changing stillness or a deafening silence. And the discovery behind it is no less disconcerting: <\/span><b>it reveals a key mechanism involved in the ageing, and regeneration, of haematopoietic stem cells<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To analyse this image from two complementary perspectives, the artistic and the scientific, we&#8217;re joined by <\/span><a href=\"https:\/\/becarios.fundacionlacaixa.org\/en\/web\/guest\/fellows\/sira-pellicer-faus-B006280\" target=\"_blank\" rel=\"noopener\"><b>Sira Pellicer<\/b><\/a><span style=\"font-weight: 400;\">, a \u201dla Caixa\u201d Foundation fellow, saxophonist and cultural manager; <\/span><a href=\"https:\/\/becarios.fundacionlacaixa.org\/en\/web\/guest\/fellows\/pablo-ianez-picazo-B005815\" target=\"_blank\" rel=\"noopener\"><b>Pablo I\u00e1\u00f1ez<\/b><\/a><span style=\"font-weight: 400;\">, a fellow and researcher in the study; and <\/span><a href=\"https:\/\/caixaresearch.org\/en\/caixaresearch-health-call-2020-project-leukaemia-ai\" target=\"_blank\" rel=\"noopener\"><b>Carolina Florian<\/b><\/a><span style=\"font-weight: 400;\">, a Health Research researcher at ICREA and leader of the work published in <\/span><a href=\"https:\/\/www.nature.com\/articles\/s43587-025-01014-w\" target=\"_blank\" rel=\"noopener\"><i><span style=\"font-weight: 400;\">Nature Aging<\/span><\/i><\/a> <i><span style=\"font-weight: 400;\">(Bellvitge Institute for Biomedical Research).<\/span><\/i><\/p>\n<p><b><i>Let&#8217;s begin with Sira.<\/i><\/b><\/p>\n<p>&nbsp;<\/p>\n<h4><b><i>Sira, what title would you give this image?\u00a0<\/i><\/b><\/h4>\n<p><b>Sira (S):<\/b><span style=\"font-weight: 400;\"> I see a silent material, loaded with information. Something that appears still but is actually full of internal tension. The image conveys both fragility and, at the same time, a great capacity for transformation. It seems like a changing, permeable form made up of different layers.<\/span><\/p>\n<div id=\"attachment_13112\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-13112\" class=\"wp-image-13112\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores3.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores3.jpg 1920w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores3-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores3-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores3-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores3-1536x864.jpg 1536w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-13112\" class=\"wp-caption-text\"><em>Sira Pellicer<\/em><\/p><\/div>\n<p><span style=\"font-weight: 400;\">This makes me wonder whether qualities such as fragility, change and structure are really opposites or whether, on the contrary, they can exist side by side. It&#8217;s this coexistence I&#8217;ve tried to condense into the title: <\/span><b>Topography of the Living<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h4><b><i>Does it remind you of any sound or piece of music in particular?<\/i><\/b><\/h4>\n<p><b>S:<\/b><span style=\"font-weight: 400;\"> Yes, of an unmistakably contemporary musical language. Specifically, I&#8217;m thinking of <\/span><a href=\"https:\/\/www.youtube.com\/watch?v=5XZiUYDGmqA\" target=\"_blank\" rel=\"noopener\"><i><span style=\"font-weight: 400;\">mute materie<\/span><\/i><\/a><span style=\"font-weight: 400;\"> (2010), a piece for solo alto sax and electronics by Swiss composer Nadir Vassena. The title <\/span><b>suggests a tension between sound and silence<\/b><span style=\"font-weight: 400;\">: mute matter becomes audible; echoes, layers and gestures emerge.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This piece has always reminded me of matter that&#8217;s seemingly silent, structured and complex but at the same time noisy to the ears of the spectator. Something very similar to what happens with this image.<\/span><\/p>\n<p><iframe loading=\"lazy\" title=\"YouTube video player\" src=\"https:\/\/www.youtube.com\/embed\/5XZiUYDGmqA?si=l5t1f_ON-ngy5V9h\" width=\"400\" height=\"225\" frameborder=\"0\" allowfullscreen=\"allowfullscreen\" data-mce-fragment=\"1\"><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<h4><b><i>Carolina, what are we actually seeing in this image?<\/i><\/b><\/h4>\n<p><b>Carolina (C):<\/b><span style=\"font-weight: 400;\"> It&#8217;s an <\/span><b>aged haematopoietic stem cell<\/b><span style=\"font-weight: 400;\">, a type of cell located in the bone marrow whose function is to produce blood cells throughout the lifetime.<\/span><\/p>\n<div id=\"attachment_13124\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-13124\" class=\"wp-image-13124\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores.jpg 1920w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores-1536x864.jpg 1536w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-13124\" class=\"wp-caption-text\"><em>Carolina Florian<\/em><\/p><\/div>\n<p><b>The active RhoA protein is shown in red and the cell nucleus in grey.<\/b><span style=\"font-weight: 400;\"> In aged stem cells, RhoA is overactivated, causing mechanical alterations in the nucleus, modifying its shape and function.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h4><b><i>Pablo, Carolina, why is this mechanical alteration so important?<\/i><\/b><\/h4>\n<p><b>C:<\/b><span style=\"font-weight: 400;\"> Because the nucleus isn&#8217;t just a container for DNA. It&#8217;s a central node for mechanical signals that regulate how the cell functions. When this is disrupted, the cell loses its ability to function properly. In our study, we&#8217;ve demonstrated that, by reducing RhoA activity with an <\/span><b>inhibitor called Rhosin<\/b><span style=\"font-weight: 400;\">, we can reverse these mechanical alterations and rejuvenate the function of haematopoietic stem cells.<\/span><\/p>\n<p><b>Pablo (P):<\/b><span style=\"font-weight: 400;\"> This finding is particularly relevant, not only because it provides further evidence of the role played by the cell&#8217;s nucleus as a signalling centre for the mechanical forces that regulate stem cell ageing, but also because it <\/span><b>identifies a specific way to modulate this process, improving the function of aged cells<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<div id=\"attachment_13120\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-13120\" class=\"wp-image-13120\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores2.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores2.jpg 1920w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores2-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores2-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores2-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_Investigadores2-1536x864.jpg 1536w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-13120\" class=\"wp-caption-text\"><em>Pablo I\u00e1\u00f1ez<\/em><\/p><\/div>\n<p>&nbsp;<\/p>\n<h4><b><i>What are the implications of this discovery?<\/i><\/b><\/h4>\n<p><b>C:<\/b><span style=\"font-weight: 400;\"> Haematopoietic stem cells are responsible for generating all blood cells. Their ageing is linked to <\/span><b>cardiovascular diseases, infections, leukaemia and a reduced immune system response<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">By rejuvenating these cells, we can get the entire haematopoietic system to function again like it does in a young organism, paving the way to improving the health of older people and potentially increasing life expectancy, as already noted in <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41536-022-00275-y\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">previous studies by the laboratory<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><b><i>We can&#8217;t end this interview without answering a key question. Sira, do you think that science and art are closer than we imagine?<\/i><\/b><\/p>\n<p><b>S:<\/b><span style=\"font-weight: 400;\"> Yes. Although they&#8217;re often presented as opposites, both stem from curiosity and an exploration of the unknown. Both scientists and artists observe, ask questions and experiment. Their language and objectives may differ but both share the same basis: <\/span><b>the need to understand, represent and make sense of the world around us<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p>&nbsp;<\/p>\n<h4><b><i>A new map of the living<\/i><\/b><\/h4>\n<p><span style=\"font-weight: 400;\">This study not only expands our knowledge of stem cell ageing but also shows that <\/span><b>how they function depends on an internal architecture that&#8217;s constantly adjusting<\/b><span style=\"font-weight: 400;\">. A microscopic topography made up of layers, tensions and balances.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">From this perspective, <\/span><b><i>Topography of the Living<\/i><\/b><span style=\"font-weight: 400;\"> serves as an accurate metaphor: a way of naming how form, structure, and cellular mechanics condition life and its capacity to regenerate itself.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-13108\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-scaled.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-scaled.jpg 2560w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<p>If we could perceive it, what sound would ageing make? What notes would represent the changes in shape, structure and colour that occur over the years? And, conversely, what signals would our body emit if it were capable of reversing that process?<\/p>\n<p>Perhaps such a sound exists but we&#8217;re simply not capable of hearing it. Something similar occurs in our latest <i>Snapshot of the Month<\/i>. As if we were experiencing <a href=\"https:\/\/www.quironsalud.com\/blogs\/es\/neuropediatra\/sinestesia-fenomeno-neurologico-arte-ciencia-i-parte\" target=\"_blank\" rel=\"noopener\">sensory synaesthesia<\/a>, the scientific image in question awakens seemingly unconnected or even contradictory sensations: a changing stillness or a deafening silence. And the discovery behind it is no less disconcerting: it reveals a key mechanism involved in the ageing,<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[601,600],"tags":[],"class_list":["post-13093","post","type-post","status-publish","format-standard","hentry","category-research","category-science-outreach"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Snapshot of the month: \u201cTopography of the Living\u201d - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Snapshot of the month: \u201cTopography of the Living\u201d - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"If we could perceive it, what sound would ageing make? What notes would represent the changes in shape, structure and colour that occur over the years? And, conversely, what signals would our body emit if it were capable of reversing that process? Perhaps such a sound exists but we&#8217;re simply not capable of hearing it. Something similar occurs in our latest Snapshot of the Month. As if we were experiencing sensory synaesthesia, the scientific image in question awakens seemingly unconnected or even contradictory sensations: a changing stillness or a deafening silence. And the discovery behind it is no less disconcerting: it reveals a key mechanism involved in the ageing,\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/\" \/>\n<meta property=\"og:site_name\" content=\"Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-17T09:00:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1440\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Ubikmedia\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ubikmedia\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/\",\"url\":\"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/\",\"name\":\"Snapshot of the month: \u201cTopography of the Living\u201d - Blog CaixaCi\u00e8ncia\",\"isPartOf\":{\"@id\":\"https:\/\/blog.caixaresearch.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-scaled.jpg\",\"datePublished\":\"2026-02-17T09:00:11+00:00\",\"author\":{\"@id\":\"https:\/\/blog.caixaresearch.org\/#\/schema\/person\/2b9d5310c27055b4862191402c387fca\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/#primaryimage\",\"url\":\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-scaled.jpg\",\"contentUrl\":\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2026\/02\/Blog_ImgPrincipal-scaled.jpg\"},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/blog.caixaresearch.org\/#website\",\"url\":\"https:\/\/blog.caixaresearch.org\/\",\"name\":\"Blog CaixaCi\u00e8ncia\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/blog.caixaresearch.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/blog.caixaresearch.org\/#\/schema\/person\/2b9d5310c27055b4862191402c387fca\",\"name\":\"Ubikmedia\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/blog.caixaresearch.org\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/ccc66bc497f8ba496f9d06e5a58a91de?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/ccc66bc497f8ba496f9d06e5a58a91de?s=96&d=mm&r=g\",\"caption\":\"Ubikmedia\"},\"url\":\"https:\/\/blog.caixaresearch.org\/en\/author\/ubikmedia\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Snapshot of the month: \u201cTopography of the Living\u201d - Blog CaixaCi\u00e8ncia","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blog.caixaresearch.org\/instantanea-del-mes-topografia-de-lo-vivo\/","og_locale":"en_US","og_type":"article","og_title":"Snapshot of the month: \u201cTopography of the Living\u201d - Blog CaixaCi\u00e8ncia","og_description":"If we could perceive it, what sound would ageing make? 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