{"id":9890,"date":"2025-03-11T11:14:03","date_gmt":"2025-03-11T10:14:03","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=9890"},"modified":"2025-03-11T14:36:13","modified_gmt":"2025-03-11T13:36:13","slug":"instantania-caixaresearch-la-beta-amiloide-un-actor-clau-de-lalzheimer","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-la-beta-amiloide-un-actor-clau-de-lalzheimer\/","title":{"rendered":"Instant\u00e0nia CaixaResearch: La beta amiloide, un actor clau des de les fases primerenques de l\u2019Alzheimer"},"content":{"rendered":"

\"\"<\/p>\n

L\u2019Alzheimer \u00e9s la causa m\u00e9s comuna de dem\u00e8ncia i, malgrat que t\u00e9 un gran impacte, encara no s\u2019ha trobat cap cura efectiva per a aquesta malaltia. L\u2019impacte que causa en la societat \u00e9s enorme i es calcula que el 2050 es triplicar\u00e0 el nombre de casos, ja que es passar\u00e0 dels 1,2 milions de malalts actuals a Espanya als 3,6 milions. A mesura que la malaltia avan\u00e7a es produeix una neurodegeneraci\u00f3 progressiva que afecta no tan sols la mem\u00f2ria, sin\u00f3 tamb\u00e9 la capacitat de relacionar-se, i fins i tot la pr\u00f2pia identitat.<\/span><\/p>\n

Durant anys es va creure que el dany cerebral associat a l\u2019Alzheimer, especialment a les regions essencials per a la mem\u00f2ria, es produ\u00efa \u00fanicament<\/span> quan hi eren presents dues prote\u00efnes: la beta amiloide i la tau<\/b>. Tanmateix, aquesta hip\u00f2tesi podria estar a punt de canviar.<\/span><\/p>\n

Un estudi del<\/span> Barcelona\u03b2eta Brain Research Center (<\/b>BBRC<\/b><\/a>)<\/b>, centre de recerca de la <\/span>Fundaci\u00f3 Pasqual Maragall<\/span><\/a>, ha identificat que<\/span> l\u2019acumulaci\u00f3 de la beta amiloide, per si sola, pot causar dany cerebral en les etapes primerenques de la malaltia<\/b>. El descobriment, publicat a la revista <\/span>Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association<\/span><\/i><\/a>, ha estat possible gr\u00e0cies a les mostres de l\u00edquid cefalorraquidi de 360 <\/span>voluntaris de la <\/b>cohort Alfa<\/b><\/a>, impulsada per la Fundaci\u00f3 \u201dla Caixa\u201d<\/b>, a m\u00e9s de l\u2019\u00fas de resson\u00e0ncies magn\u00e8tiques d\u2019alta resoluci\u00f3.\u00a0<\/span><\/p>\n

Els resultats apunten que l\u2019acumulaci\u00f3 de la beta amiloide (com s\u2019observa en la imatge) pot ser <\/span>un indicador primerenc<\/b> de canvis estructurals al cervell i d\u2019un possible deteriorament de la mem\u00f2ria abans de l\u2019aparici\u00f3 de s\u00edmptomes evidents de la malaltia. La prote\u00efna sembla que <\/span>afecta directament l\u2019hipocamp<\/b>, una regi\u00f3 clau per a la mem\u00f2ria, per la qual cosa actuar sobre la beta amiloide de manera anticipada podria reduir significativament els riscos associats a l\u2019Alzheimer.\u00a0<\/span><\/p>\n

\u00abAquest descobriment subratlla <\/span>la import\u00e0ncia de la detecci\u00f3 primerenca i la prevenci\u00f3<\/b>. A m\u00e9s, refor\u00e7a la necessitat dels assaigs cl\u00ednics dirigits a persones amb perfils de risc abans que l\u2019Alzheimer es comenci a manifestar\u00bb, explica Raffaele Cacciaglia, investigador del BBRC i l\u00edder de l\u2019estudi. T\u2019expliquem m\u00e9s coses sobre l\u2019estudi en aquest fil de X. <\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/p>\n

L\u2019Alzheimer \u00e9s la causa m\u00e9s comuna de dem\u00e8ncia i, malgrat que t\u00e9 un gran impacte, encara no s\u2019ha trobat cap cura efectiva per a aquesta malaltia. L\u2019impacte que causa en la societat \u00e9s enorme i es calcula que el 2050 es triplicar\u00e0 el nombre de casos, ja que es passar\u00e0 dels 1,2 milions de malalts actuals a Espanya als 3,6 milions. A mesura que la malaltia avan\u00e7a es produeix una neurodegeneraci\u00f3 progressiva que afecta no tan sols la mem\u00f2ria, sin\u00f3 tamb\u00e9 la capacitat de relacionar-se, i fins i tot la pr\u00f2pia identitat.<\/p>\n

Durant anys es va creure que el dany cerebral associat a l\u2019Alzheimer, especialment a les regions essencials per a la mem\u00f2ria,<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[340],"tags":[],"class_list":["post-9890","post","type-post","status-publish","format-standard","hentry","category-sense-categoria"],"acf":[],"yoast_head":"\nInstant\u00e0nia CaixaResearch: La beta amiloide, un actor clau des de les fases primerenques de l\u2019Alzheimer - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-la-beta-amiloide-un-actor-clau-de-lalzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Instant\u00e0nia CaixaResearch: La beta amiloide, un actor clau des de les fases primerenques de l\u2019Alzheimer - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"L\u2019Alzheimer \u00e9s la causa m\u00e9s comuna de dem\u00e8ncia i, malgrat que t\u00e9 un gran impacte, encara no s\u2019ha trobat cap cura efectiva per a aquesta malaltia. 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