{"id":9605,"date":"2025-01-24T09:40:20","date_gmt":"2025-01-24T08:40:20","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=9605"},"modified":"2025-01-24T11:12:29","modified_gmt":"2025-01-24T10:12:29","slug":"instantania-caixaresearch-lestudi-de-les-tubulines-obre-noves-possibilitats-per-abordar-el-cancer","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-lestudi-de-les-tubulines-obre-noves-possibilitats-per-abordar-el-cancer\/","title":{"rendered":"Instant\u00e0nia CaixaResearch: L\u2019estudi de les tubulines obre noves possibilitats per abordar el c\u00e0ncer"},"content":{"rendered":"

\"\"<\/b><\/p>\n

Al llarg de la vida, les c\u00e8l\u00b7lules del nostre cos es divideixen uns 10.000 trilions de vegades.<\/b> Aquest proc\u00e9s, acuradament regulat, permet que una c\u00e8l\u00b7lula original es dupliqui i doni lloc a dues c\u00e8l\u00b7lules filles amb un repartiment prec\u00eds d\u2019una c\u00f2pia del seu ADN a cadascuna.\u00a0<\/span><\/p>\n

En aquest proc\u00e9s de repartiment dels cromosomes entre les dues c\u00e8l\u00b7lules filles hi tenen un paper clau els microt\u00fabuls.<\/b> Els microt\u00fabuls formen l\u2019\u00abesquelet\u00bb cel\u00b7lular, la bastida que es munta i es desmunta per sostenir l\u2019arquitectura de la c\u00e8l\u00b7lula i coordinar-ne els moviments. I les tubulines s\u00f3n les prote\u00efnes encarregades de la formaci\u00f3 i de la din\u00e0mica d\u2019aquests microt\u00fabuls.\u00a0<\/span><\/p>\n

Fa m\u00e9s de 40 anys es va descriure el que avui es coneix com el <\/span>codi de la tubulina<\/i><\/b>: la diversitat de variants estructurals i modificacions qu\u00edmiques que experimenten aquestes prote\u00efnes, que dictaran com i quan han d\u2019actuar els microt\u00fabuls. Tot i que molts d\u2019aquests processos ja es coneixen, la comprensi\u00f3 completa de com afecten la divisi\u00f3 cel\u00b7lular encara \u00e9s una \u00e0rea activa d\u2019investigaci\u00f3.\u00a0<\/span><\/p>\n

Un nou <\/span>estudi<\/span><\/a> liderat per <\/b>Helder Maiato<\/b><\/a>, investigador a l\u2019Institut d\u2019Investigaci\u00f3 i Innovaci\u00f3 en Salut (i3S) de Porto, ha identificat <\/span>el paper crucial d\u2019una modificaci\u00f3 qu\u00edmica a l\u2019alfa-tubulina, la <\/b>detirosinaci\u00f3<\/i><\/b>, per garantir que els microt\u00fabuls guien correctament el moviment dels cromosomes i l\u2019inici oport\u00fa del seu repartiment durant la divisi\u00f3 cel\u00b7lular<\/b>. Si aix\u00f2 falla, les c\u00e8l\u00b7lules es podrien dividir de manera descontrolada i propiciar el desenvolupament d\u2019un c\u00e0ncer.\u00a0<\/span><\/p>\n

Aquest descobriment no sols amplia la nostra comprensi\u00f3 sobre el codi de la tubulina<\/span>,<\/span><\/i> sin\u00f3 que tamb\u00e9 obre noves possibilitats en la recerca de <\/span>noves estrat\u00e8gies per millorar el diagn\u00f2stic i el tractament del c\u00e0ncer<\/b>. Descobreix-ne els detalls en aquest fil amb la nova Instant\u00e0nia CaixaResearch: <\/span>Enlla\u00e7 fil<\/span><\/i><\/a>.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/p>\n

Al llarg de la vida, les c\u00e8l\u00b7lules del nostre cos es divideixen uns 10.000 trilions de vegades. Aquest proc\u00e9s, acuradament regulat, permet que una c\u00e8l\u00b7lula original es dupliqui i doni lloc a dues c\u00e8l\u00b7lules filles amb un repartiment prec\u00eds d\u2019una c\u00f2pia del seu ADN a cadascuna.\u00a0<\/p>\n

En aquest proc\u00e9s de repartiment dels cromosomes entre les dues c\u00e8l\u00b7lules filles hi tenen un paper clau els microt\u00fabuls. Els microt\u00fabuls formen l\u2019\u00abesquelet\u00bb cel\u00b7lular, la bastida que es munta i es desmunta per sostenir l\u2019arquitectura de la c\u00e8l\u00b7lula i coordinar-ne els moviments. I les tubulines s\u00f3n les prote\u00efnes encarregades de la formaci\u00f3 i de la din\u00e0mica d\u2019aquests microt\u00fabuls.\u00a0<\/p>\n

Fa m\u00e9s de 40 anys es va descriure el que avui es coneix com el codi de la tubulina<\/i>: la diversitat de variants estructurals i modificacions qu\u00edmiques que experimenten aquestes prote\u00efnes,<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[520,519],"tags":[],"class_list":["post-9605","post","type-post","status-publish","format-standard","hentry","category-divulgacio-cientifica","category-investigacio"],"acf":[],"yoast_head":"\nInstant\u00e0nia CaixaResearch: L\u2019estudi de les tubulines obre noves possibilitats per abordar el c\u00e0ncer - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-lestudi-de-les-tubulines-obre-noves-possibilitats-per-abordar-el-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Instant\u00e0nia CaixaResearch: L\u2019estudi de les tubulines obre noves possibilitats per abordar el c\u00e0ncer - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Al llarg de la vida, les c\u00e8l\u00b7lules del nostre cos es divideixen uns 10.000 trilions de vegades. 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