{"id":9281,"date":"2024-11-29T11:24:50","date_gmt":"2024-11-29T10:24:50","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=9281"},"modified":"2024-11-29T11:25:16","modified_gmt":"2024-11-29T10:25:16","slug":"instantania-caixaresearch-els-sintrocits-una-estrategia-innovadora-en-el-control-de-la-grip","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-els-sintrocits-una-estrategia-innovadora-en-el-control-de-la-grip\/","title":{"rendered":"Instant\u00e0nia CaixaResearch: Els sintr\u00f2cits\u00a9, una estrat\u00e8gia innovadora en el control de la grip"},"content":{"rendered":"

\"\"<\/p>\n

Cada temporada, amb l\u2019arribada de la grip, les vacunes tornen a ser not\u00edcia. Tanmateix, la veritable batalla t\u00e9 lloc durant tot l\u2019any en laboratoris d\u2019arreu del m\u00f3n on els investigadors intenten anticipar-se a un virus que, gr\u00e0cies a l\u2019alta capacitat de mutaci\u00f3 que t\u00e9, es reinventa constantment per eludir les defenses del nostre organisme.<\/p>\n

Aquesta habilitat d\u2019adaptaci\u00f3 obliga els cient\u00edfics a actualitzar les vacunes una vegada i una altra en un esfor\u00e7 per mantenir la poblaci\u00f3 protegida davant de les variants emergents.<\/p>\n

Actualment, un m\u00e8tode avalat per l\u2019Organitzaci\u00f3 Mundial de la Salut (OMS)<\/a> \u00e9s clau per monitorar el virus<\/strong>: els assajos d\u2019hemaglutinaci\u00f3 (HA) i inhibici\u00f3 de l\u2019hemaglutinaci\u00f3 (HAI). Aquestes t\u00e8cniques, que es basen en la capacitat del virus de la grip per unir-se als gl\u00f2buls vermells<\/strong> (eritr\u00f2cits), permeten als cient\u00edfics caracteritzar els virus circulants a cada estaci\u00f3 i estudiar la resposta immunol\u00f2gica de la poblaci\u00f3. Tot i que s\u00f3n efica\u00e7os i econ\u00f2mics, depenen de gl\u00f2buls vermells \u00abfrescos\u00bb, amb una vida \u00fatil de tan sols una setmana, cosa que obliga a treballar contra rellotge.<\/p>\n

Per\u00f2 qu\u00e8 passaria si existissin gl\u00f2buls vermells artificials, dissenyats espec\u00edficament per a aquestes t\u00e8cniques, que es poguessin produir en grans quantitats, que fossin m\u00e9s estables i que, a m\u00e9s, facilitessin l\u2019estandarditzaci\u00f3 mundial dels m\u00e8todes de l\u2019OMS? Aquesta va ser la visi\u00f3 d\u2019Eva Baldrich<\/strong><\/a>, que fa set anys va decidir donar forma al projecte Sintr\u00f2cit\u00a9<\/strong>.<\/p>\n

Al Vall d\u2019Hebron Institut de Recerca de Barcelona, l\u2019Eva i el seu equip van crear unes micropart\u00edcules que emulen els gl\u00f2buls vermells<\/strong> i que porten incorporats en superf\u00edcie receptors espec\u00edfics del virus de la grip, i les van batejar com a Sintr\u00f2cits<\/em><\/strong>. En els assajos d\u2019aglutinaci\u00f3 amb Sintr\u00f2cits<\/em> (SynA), aquestes part\u00edcules van mostrar una uni\u00f3 r\u00e0pida i espec\u00edfica amb diferents soques de virus que imita els resultats obtinguts amb els gl\u00f2buls vermells.<\/p>\n

Fins ara, aquests Sintr\u00f2cits<\/em> han demostrat m\u00e9s reproductibilitat i estabilitat i,<\/strong> a difer\u00e8ncia dels gl\u00f2buls vermells frescos, es poden conservar deshidratats<\/strong>, la qual cosa en facilita la producci\u00f3 a gran escala, el transport i l\u2019emmagatzematge.<\/p>\n

En aquests moments, la tecnologia est\u00e0 sent testada en col\u00b7laboraci\u00f3 amb investigadors del Centre per al Control i la Prevenci\u00f3 de Malalties (CDC) d\u2019Atlanta<\/strong><\/a>, als Estats Units, el centre de malalties infeccioses m\u00e9s important del m\u00f3n, una gran fita per al projecte Sintr\u00f2cit\u00a9.<\/p>\n

Ara, l\u2019equip de l\u2019Eva s\u2019enfronta a un nou repte: millorar la sensibilitat dels Sintr\u00f2cits<\/em>, ampliar la seva capacitat per detectar m\u00e9s virus i alhora reduir els costos<\/strong> de producci\u00f3. El pas seg\u00fcent \u00e9s trobar aliats en la ind\u00fastria per escalar la producci\u00f3 i portar aquesta soluci\u00f3 tan innovadora al mercat.<\/p>\n

Si vols m\u00e9s informaci\u00f3 sobre aquesta investigaci\u00f3, et convidem a seguir el nostre fil a X<\/a><\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/p>\n

Cada temporada, amb l\u2019arribada de la grip, les vacunes tornen a ser not\u00edcia. Tanmateix, la veritable batalla t\u00e9 lloc durant tot l\u2019any en laboratoris d\u2019arreu del m\u00f3n on els investigadors intenten anticipar-se a un virus que, gr\u00e0cies a l\u2019alta capacitat de mutaci\u00f3 que t\u00e9, es reinventa constantment per eludir les defenses del nostre organisme.<\/p>\n

Aquesta habilitat d\u2019adaptaci\u00f3 obliga els cient\u00edfics a actualitzar les vacunes una vegada i una altra en un esfor\u00e7 per mantenir la poblaci\u00f3 protegida davant de les variants emergents.<\/p>\n

Actualment, un m\u00e8tode avalat per l\u2019Organitzaci\u00f3 Mundial de la Salut (OMS)<\/a> \u00e9s clau per monitorar el virus: els assajos d\u2019hemaglutinaci\u00f3 (HA) i inhibici\u00f3 de l\u2019hemaglutinaci\u00f3 (HAI).<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[340],"tags":[],"class_list":["post-9281","post","type-post","status-publish","format-standard","hentry","category-sense-categoria"],"acf":[],"yoast_head":"\nInstant\u00e0nia CaixaResearch: Els sintr\u00f2cits\u00a9, una estrat\u00e8gia innovadora en el control de la grip - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-els-sintrocits-una-estrategia-innovadora-en-el-control-de-la-grip\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Instant\u00e0nia CaixaResearch: Els sintr\u00f2cits\u00a9, una estrat\u00e8gia innovadora en el control de la grip - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Cada temporada, amb l\u2019arribada de la grip, les vacunes tornen a ser not\u00edcia. Tanmateix, la veritable batalla t\u00e9 lloc durant tot l\u2019any en laboratoris d\u2019arreu del m\u00f3n on els investigadors intenten anticipar-se a un virus que, gr\u00e0cies a l\u2019alta capacitat de mutaci\u00f3 que t\u00e9, es reinventa constantment per eludir les defenses del nostre organisme. Aquesta habilitat d\u2019adaptaci\u00f3 obliga els cient\u00edfics a actualitzar les vacunes una vegada i una altra en un esfor\u00e7 per mantenir la poblaci\u00f3 protegida davant de les variants emergents. 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