{"id":9041,"date":"2024-10-30T10:00:37","date_gmt":"2024-10-30T09:00:37","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=9041"},"modified":"2024-10-30T10:06:21","modified_gmt":"2024-10-30T09:06:21","slug":"instantania-caixaresearch-avencos-per-millorar-leficacia-de-les-terapies-car-t-en-tumors-solids","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-avencos-per-millorar-leficacia-de-les-terapies-car-t-en-tumors-solids\/","title":{"rendered":"Instant\u00e0nia CaixaResearch: Aven\u00e7os per millorar l\u2019efic\u00e0cia de les ter\u00e0pies CAR-T en tumors s\u00f2lids"},"content":{"rendered":"

\"\"<\/span><\/p>\n

En aquesta nova edici\u00f3 d\u2019Instant\u00e0nies CaixaResearch us presentem un aven\u00e7 clau per millorar una de les ter\u00e0pies m\u00e9s innovadores en el tractament del c\u00e0ncer: les immunoter\u00e0pies CAR-T.\u00a0<\/span><\/p>\n

Aquestes ter\u00e0pies consisteixen a modificar gen\u00e8ticament les c\u00e8l\u00b7lules T immunit\u00e0ries del mateix pacient per convertir-les en c\u00e8l\u00b7lules CAR-T, capaces de recon\u00e8ixer i atacar les c\u00e8l\u00b7lules canceroses. Si b\u00e9 s\u2019ha demostrat que les ter\u00e0pies CAR-T s\u00f3n molt eficaces contra c\u00e0ncers de la sang, com la leuc\u00e8mia i els limfomes, <\/span>perden significativament l\u2019efectivitat en tumors s\u00f2lids<\/b>, com ara els c\u00e0ncers de mama, d\u2019ovari o g\u00e0strics.<\/span><\/p>\n

Aix\u00f2 passa perqu\u00e8 els tumors s\u00f2lids han desenvolupat mecanismes que els permeten evadir l\u2019atac de les c\u00e8l\u00b7lules CAR-T. Un d\u2019aquests mecanismes est\u00e0 causat per la uni\u00f3 de dues prote\u00efnes: la prote\u00efna PD-L1, present a la superf\u00edcie de les c\u00e8l\u00b7lules tumorals, i la PD-1, situada a les c\u00e8l\u00b7lules CAR-T. Quan aquestes prote\u00efnes interaccionen actuen com un \u00abbot\u00f3 d\u2019apagada\u00bb que desactiva les c\u00e8l\u00b7lules CAR-T i impedeix que ataquin el tumor efica\u00e7ment.\u00a0<\/span><\/p>\n

Tot i que investigacions pr\u00e8vies suggerien que bloquejar aquesta via podria millorar l\u2019efic\u00e0cia de les ter\u00e0pies CAR-T, els resultats fins ara eren contradictoris. No obstant aix\u00f2, un nou estudi del grup d\u2019Immunoter\u00e0pies Cel\u00b7lulars per al C\u00e0ncer de l\u2019Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS-HCB), liderat per la investigadora de la nostra xarxa <\/span>S\u00f2nia Guedan<\/span><\/a>, ha fet llum sobre aquesta q\u00fcesti\u00f3.\u00a0<\/span><\/p>\n

En els seus experiments, <\/span>publicats a <\/span>Nature<\/span><\/i><\/a>, van observar que algunes c\u00e8l\u00b7lules CAR-T tenen m\u00e9s afinitat pel tumor que d\u2019altres, \u00e9s a dir, que el reconeixen i l\u2019ataquen amb m\u00e9s efic\u00e0cia. A m\u00e9s, van veure que aquestes c\u00e8l\u00b7lules m\u00e9s afins tamb\u00e9 aconsegueixen resistir millor el bloqueig de PD-1\/PD-L1 en comparaci\u00f3 amb les que tenen menys afinitat. Aquests resultats indiquen que<\/span> ajustar l\u2019afinitat de les c\u00e8l\u00b7lules CAR-T podria ser clau per augmentar-ne l\u2019efic\u00e0cia contra els tumors s\u00f2lids<\/b> i superar aix\u00ed una barrera que fins ara limita el potencial de les ter\u00e0pies CAR-T en aquests tipus de c\u00e0ncer. Aquest descobriment no solament amplia la nostra comprensi\u00f3 dels mecanismes de defensa tumoral, sin\u00f3 que tamb\u00e9 subratlla la import\u00e0ncia de la recerca b\u00e0sica en biologia molecular. En el futur, aquest aven\u00e7 podria ajudar a optimitzar les ter\u00e0pies actuals i accelerar el desenvolupament de nous tractaments, de manera que ampliaria les opcions terap\u00e8utiques disponibles i n\u2019incrementaria l\u2019efic\u00e0cia. <\/span>Enlla\u00e7 al fil de X<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/p>\n

En aquesta nova edici\u00f3 d\u2019Instant\u00e0nies CaixaResearch us presentem un aven\u00e7 clau per millorar una de les ter\u00e0pies m\u00e9s innovadores en el tractament del c\u00e0ncer: les immunoter\u00e0pies CAR-T.\u00a0<\/p>\n

Aquestes ter\u00e0pies consisteixen a modificar gen\u00e8ticament les c\u00e8l\u00b7lules T immunit\u00e0ries del mateix pacient per convertir-les en c\u00e8l\u00b7lules CAR-T, capaces de recon\u00e8ixer i atacar les c\u00e8l\u00b7lules canceroses. Si b\u00e9 s\u2019ha demostrat que les ter\u00e0pies CAR-T s\u00f3n molt eficaces contra c\u00e0ncers de la sang, com la leuc\u00e8mia i els limfomes, perden significativament l\u2019efectivitat en tumors s\u00f2lids, com ara els c\u00e0ncers de mama, d\u2019ovari o g\u00e0strics.<\/p>\n

Aix\u00f2 passa perqu\u00e8 els tumors s\u00f2lids han desenvolupat mecanismes que els permeten evadir l\u2019atac de les c\u00e8l\u00b7lules CAR-T. Un d\u2019aquests mecanismes est\u00e0 causat per la uni\u00f3 de dues prote\u00efnes: la prote\u00efna PD-L1,<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[340],"tags":[],"class_list":["post-9041","post","type-post","status-publish","format-standard","hentry","category-sense-categoria"],"acf":[],"yoast_head":"\nInstant\u00e0nia CaixaResearch: Aven\u00e7os per millorar l\u2019efic\u00e0cia de les ter\u00e0pies CAR-T en tumors s\u00f2lids - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-avencos-per-millorar-leficacia-de-les-terapies-car-t-en-tumors-solids\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Instant\u00e0nia CaixaResearch: Aven\u00e7os per millorar l\u2019efic\u00e0cia de les ter\u00e0pies CAR-T en tumors s\u00f2lids - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"En aquesta nova edici\u00f3 d\u2019Instant\u00e0nies CaixaResearch us presentem un aven\u00e7 clau per millorar una de les ter\u00e0pies m\u00e9s innovadores en el tractament del c\u00e0ncer: les immunoter\u00e0pies CAR-T.\u00a0 Aquestes ter\u00e0pies consisteixen a modificar gen\u00e8ticament les c\u00e8l\u00b7lules T immunit\u00e0ries del mateix pacient per convertir-les en c\u00e8l\u00b7lules CAR-T, capaces de recon\u00e8ixer i atacar les c\u00e8l\u00b7lules canceroses. Si b\u00e9 s\u2019ha demostrat que les ter\u00e0pies CAR-T s\u00f3n molt eficaces contra c\u00e0ncers de la sang, com la leuc\u00e8mia i els limfomes, perden significativament l\u2019efectivitat en tumors s\u00f2lids, com ara els c\u00e0ncers de mama, d\u2019ovari o g\u00e0strics. Aix\u00f2 passa perqu\u00e8 els tumors s\u00f2lids han desenvolupat mecanismes que els permeten evadir l\u2019atac de les c\u00e8l\u00b7lules CAR-T. 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