{"id":8615,"date":"2024-07-31T15:36:04","date_gmt":"2024-07-31T14:36:04","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=8615"},"modified":"2024-07-31T16:08:23","modified_gmt":"2024-07-31T15:08:23","slug":"instantania-caixaresearch-la-reduccio-del-flux-sanguini-cerebral-podria-ser-un-senyal-primerenc-de-la-malaltia-dalzheimer","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-la-reduccio-del-flux-sanguini-cerebral-podria-ser-un-senyal-primerenc-de-la-malaltia-dalzheimer\/","title":{"rendered":"Instant\u00e0nia CaixaResearch: La reducci\u00f3 del flux sanguini cerebral podria ser un senyal primerenc de la malaltia d\u2019Alzheimer"},"content":{"rendered":"

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El flux sanguini \u00e9s essencial per subministrar oxigen i glucosa al cervell, i s\u2019ha de mantenir dins dels nivells normals per garantir la salut i el bon funcionament d\u2019aquest \u00f2rgan. En malalties neurol\u00f2giques com l\u2019Alzheimer es pot veure comprom\u00e8s. Per aix\u00f2, mesurar aquests canvis abans que apareguin els primers s\u00edmptomes de la malaltia \u00e9s crucial per poder desenvolupar estrat\u00e8gies de seguiment i prevenci\u00f3 m\u00e9s efectives<\/strong>.<\/p>\n

Fins ara, la t\u00e8cnica arterial spin labeling<\/em> (ASL) ha estat l\u2019eina principal per mesurar el flux<\/strong> sanguini cerebral. No obstant aix\u00f2, l\u2019ASL t\u00e9 limitacions<\/strong> i no \u00e9s capa\u00e7 de detectar alteracions subtils en les etapes inicials de la malaltia.<\/p>\n

I si pogu\u00e9ssim millorar la sensibilitat d\u2019aquesta t\u00e8cnica i saber qu\u00e8 passa en les etapes asimptom\u00e0tiques? Aix\u00f2 \u00e9s precisament el que s\u2019ha aconseguit en un estudi liderat pel Barcelona\u03b2eta Brain Research Center (BBRC)<\/a> i publicat a la revista Alzheimer\u2019s & Dementia<\/em><\/a>.<\/strong><\/p>\n

L\u2019estudi s\u2019ha dut a terme amb una t\u00e8cnica m\u00e9s sensible i precisa per mesurar el flux sanguini<\/strong> cerebral, desenvolupada pel Centre M\u00e8dic de la Universitat de Leiden en col\u00b7laboraci\u00f3 amb Philips: la time-encoded arterial spin labeling<\/em> (teASL)<\/strong>.<\/p>\n

Gr\u00e0cies a aquesta nova t\u00e8cnica i a la participaci\u00f3 de 59 voluntaris, els investigadors han demostrat per primera vegada que el flux sanguini cerebral disminueix en individus amb Alzheimer en les primeres fases de la malaltia, molt abans que es manifestin els s\u00edmptomes cl\u00ednics. Dels participants sans, una trentena pertanyen a l\u2019estudi Alfa del BBRC, impulsat per la Fundaci\u00f3 \u201dla Caixa\u201d<\/strong>.<\/p>\n

En l\u2019estudi tamb\u00e9 s\u2019ha aconseguit associar aquesta disminuci\u00f3 del flux sanguini amb biomarcadors concrets associats a la disfunci\u00f3 sin\u00e0ptica<\/strong> (alteracions en la comunicaci\u00f3 entre neurones) i a la neurodegeneraci\u00f3<\/strong>.<\/p>\n

Aquestes troballes obren noves possibilitats per detectar l\u2019Alzheimer en les etapes m\u00e9s primerenques i per desenvolupar noves estrat\u00e8gies de prevenci\u00f3.<\/strong><\/p>\n

T\u2019expliquem m\u00e9s sobre aquest estudi en aquest fil de X<\/a>.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/p>\n

El flux sanguini \u00e9s essencial per subministrar oxigen i glucosa al cervell, i s\u2019ha de mantenir dins dels nivells normals per garantir la salut i el bon funcionament d\u2019aquest \u00f2rgan. En malalties neurol\u00f2giques com l\u2019Alzheimer es pot veure comprom\u00e8s. Per aix\u00f2, mesurar aquests canvis abans que apareguin els primers s\u00edmptomes de la malaltia \u00e9s crucial per poder desenvolupar estrat\u00e8gies de seguiment i prevenci\u00f3 m\u00e9s efectives.<\/p>\n

Fins ara, la t\u00e8cnica arterial spin labeling<\/em> (ASL) ha estat l\u2019eina principal per mesurar el flux sanguini cerebral. No obstant aix\u00f2, l\u2019ASL t\u00e9 limitacions i no \u00e9s capa\u00e7 de detectar alteracions subtils en les etapes inicials de la malaltia.<\/p>\n

I si pogu\u00e9ssim millorar la sensibilitat d\u2019aquesta t\u00e8cnica i saber qu\u00e8 passa en les etapes asimptom\u00e0tiques?<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[520],"tags":[584],"class_list":["post-8615","post","type-post","status-publish","format-standard","hentry","category-divulgacio-cientifica","tag-alzheimer-ca"],"acf":[],"yoast_head":"\nInstant\u00e0nia CaixaResearch: La reducci\u00f3 del flux sanguini cerebral podria ser un senyal primerenc de la malaltia d\u2019Alzheimer - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-la-reduccio-del-flux-sanguini-cerebral-podria-ser-un-senyal-primerenc-de-la-malaltia-dalzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Instant\u00e0nia CaixaResearch: La reducci\u00f3 del flux sanguini cerebral podria ser un senyal primerenc de la malaltia d\u2019Alzheimer - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"El flux sanguini \u00e9s essencial per subministrar oxigen i glucosa al cervell, i s\u2019ha de mantenir dins dels nivells normals per garantir la salut i el bon funcionament d\u2019aquest \u00f2rgan. En malalties neurol\u00f2giques com l\u2019Alzheimer es pot veure comprom\u00e8s. Per aix\u00f2, mesurar aquests canvis abans que apareguin els primers s\u00edmptomes de la malaltia \u00e9s crucial per poder desenvolupar estrat\u00e8gies de seguiment i prevenci\u00f3 m\u00e9s efectives. Fins ara, la t\u00e8cnica arterial spin labeling (ASL) ha estat l\u2019eina principal per mesurar el flux sanguini cerebral. No obstant aix\u00f2, l\u2019ASL t\u00e9 limitacions i no \u00e9s capa\u00e7 de detectar alteracions subtils en les etapes inicials de la malaltia. I si pogu\u00e9ssim millorar la sensibilitat d\u2019aquesta t\u00e8cnica i saber qu\u00e8 passa en les etapes asimptom\u00e0tiques?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-la-reduccio-del-flux-sanguini-cerebral-podria-ser-un-senyal-primerenc-de-la-malaltia-dalzheimer\/\" \/>\n<meta property=\"og:site_name\" content=\"Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-31T14:36:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-31T15:08:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2024\/07\/Instantaneas_Jul24_CAT_1.jpg\" \/>\n<meta name=\"author\" content=\"Ubikmedia\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ubikmedia\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-la-reduccio-del-flux-sanguini-cerebral-podria-ser-un-senyal-primerenc-de-la-malaltia-dalzheimer\/\",\"url\":\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-la-reduccio-del-flux-sanguini-cerebral-podria-ser-un-senyal-primerenc-de-la-malaltia-dalzheimer\/\",\"name\":\"Instant\u00e0nia CaixaResearch: La reducci\u00f3 del flux sanguini cerebral podria ser un senyal primerenc de la malaltia d\u2019Alzheimer - 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