{"id":6625,"date":"2023-07-03T11:52:58","date_gmt":"2023-07-03T10:52:58","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=6625"},"modified":"2023-07-03T12:37:24","modified_gmt":"2023-07-03T11:37:24","slug":"nou-biomarcador-diagnosticar-malaltia-fetge-gras-no-alcoholic","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/nou-biomarcador-diagnosticar-malaltia-fetge-gras-no-alcoholic\/","title":{"rendered":"Identificat un nou biomarcador per predir i diagnosticar la malaltia del fetge gras no alcoh\u00f2lic"},"content":{"rendered":"
\"\"D\u2019esquerra a dreta: Les investigadores de l\u2019estudi del Grup DIAMET del IISPV Victoria Ceperuelo Mallafr\u00e9, Anna Marsal Beltran i Sonia Fern\u00e1ndez-Veledo.<\/h6>\n

Un estudi liderat des de l\u2019Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), de Tarragona, i publicat a la prestigiosa revista cient\u00edfica <\/span>Metabolism<\/span><\/i> ha perm\u00e8s identificar el succinat com a nou biomarcador present a la sang per predir la malaltia del fetge gras no alcoh\u00f2lic i per confirmar-ne el seu diagn\u00f2stic<\/b>. A m\u00e9s, aquest estudi, que rep el suport de CaixaResearch, descobreix una nova funci\u00f3 del succinat i, concretament, del seu receptor SUCNR1 <\/span>com a mecanisme protector de le\u0219 c\u00e8l\u00b7lules hep\u00e0tiques<\/b>: la de prevenir l\u2019acumulaci\u00f3 de l\u00edpids a les fases inicials de la malaltia.<\/span><\/p>\n

La malaltia del fetge gras no alcoh\u00f2lic afecta el 25% de la poblaci\u00f3<\/b>. En els casos m\u00e9s greus pot derivar en una cirrosi i pot implicar un major risc de c\u00e0ncer. S’ha convertit en una de les principals causes de transplantament hep\u00e0tic. El grup DIAMET de l’IISPV (reconegut a nivell internacional per la seva recerca sobre el paper del succinat en les malalties metab\u00f2liques) treballa en aquest camp des de fa temps.<\/span><\/p>\n

L’estudi ha analitzat els nivells de succinat en sang de pacients amb sospita de patir la malaltia i que presentaven diverses alteracions metab\u00f2liques, com l’obesitat, o valors anormals relacionats amb la glucosa, els enzims hep\u00e0tics i els l\u00edpids. <\/span>Els resultats han mostrat que els pacients amb nivells elevats de succinat en sang tenen un major risc de desenvolupar la malaltia del fetge gras<\/b>. A m\u00e9s a m\u00e9s, s’ha observat que aquest metab\u00f2lit t\u00e9 un potencial similar a altres biomarcadors no invasius per a la predicci\u00f3 i confirmaci\u00f3 del diagn\u00f2stic d\u2019aquesta patologia. <\/span>La inclusi\u00f3 d’aquest par\u00e0metre a la pr\u00e0ctica cl\u00ednica podria evitar bi\u00f2psies hep\u00e0tiques, una prova invasiva que s’utilitza quan hi ha dubtes sobre l’evoluci\u00f3 de la patologia.<\/b><\/p>\n

D’altra banda, s’ha descobert que el receptor del succinat, el SUCNR1, juga un paper clau no nom\u00e9s en etapes m\u00e9s avan\u00e7ades de la malaltia com la fibrosi, com s’havia descrit en estudis previs, sin\u00f3 tamb\u00e9 en etapes m\u00e9s inicials. Utilitzant mostres de pacients amb obesitat severa i amb diferents nivells de la malaltia, aix\u00ed com estudis en ratolins i experiments amb c\u00e8l\u00b7lules,<\/span> s’ha demostrat per primera vegada que el succinat, a trav\u00e9s del seu receptor, t\u00e9 efectes protectors en les principals c\u00e8l\u00b7lules del fetge, els hepat\u00f2cits, ja que evita l’acumulaci\u00f3 de greix al fetge.<\/b> Aquest efecte protector \u00e9s fonamental a les etapes inicials, per\u00f2 no \u00e9s suficient en etapes m\u00e9s avan\u00e7ades.\u00a0<\/span><\/p>\n

Aquest estudi del Grup de Recerca DIAMET de l’IISPV-CIBERDEM-URV, sota la direcci\u00f3 dels investigadors <\/span>Sonia Fern\u00e1ndez-Veledo<\/span><\/a> i Joan Vendrell, <\/span>no nom\u00e9s contribueix a un diagn\u00f2stic m\u00e9s efectiu de la malaltia del fetge gras no alcoh\u00f2lic, sin\u00f3 que tamb\u00e9 obrir\u00e0 noves vies per al desenvolupament de f\u00e0rmacs destinats al seu tractament (fins ara inexistents).<\/b> Les investigadores de l’estudi Vict\u00f2ria Ceperuelo Mallafr\u00e9 i Anna Marsal Beltran assenyalen la import\u00e0ncia d’avan\u00e7ar en el coneixement dels processos moleculars que determinen la progressi\u00f3 de la malaltia i poder aix\u00ed desenvolupar f\u00e0rmacs dirigits a c\u00e8l\u00b7lules espec\u00edfiques. Aquest estudi s’ha dut a terme amb mostres de pacients dels hospitals universitaris Joan XXIII i Sant Joan de Reus de Tarragona, de l’Hospital Universitari Dr. Josep Trueta de Girona i de l’Hospital Cl\u00ednic Universitari Virgen de la Arrixaca, a Murcia. La recerca ha comptat amb el suport financer de la Agencia Estatal de Investigaci\u00f3n (Ministerio de Ciencia e Innovaci\u00f3n), del Instituto de Salud Carlos III, i de la Fundaci\u00f3 La Caixa, mitjan\u00e7ant diferents projectes de recerca competitius centrats en l’estudi del paper del succinat i del seu receptor amb relaci\u00f3 a malalties metab\u00f2liques amb una elevada incid\u00e8ncia a la nostra societat, com l’obesitat, la diabetis i el fetge gras. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"D\u2019esquerra a dreta: Les investigadores de l\u2019estudi del Grup DIAMET del IISPV Victoria Ceperuelo Mallafr\u00e9, Anna Marsal Beltran i Sonia Fern\u00e1ndez-Veledo.<\/p>\n

Un estudi liderat des de l\u2019Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), de Tarragona, i publicat a la prestigiosa revista cient\u00edfica Metabolism<\/i> ha perm\u00e8s identificar el succinat com a nou biomarcador present a la sang per predir la malaltia del fetge gras no alcoh\u00f2lic i per confirmar-ne el seu diagn\u00f2stic. A m\u00e9s, aquest estudi, que rep el suport de CaixaResearch, descobreix una nova funci\u00f3 del succinat i, concretament, del seu receptor SUCNR1 com a mecanisme protector de le\u0219 c\u00e8l\u00b7lules hep\u00e0tiques: la de prevenir l\u2019acumulaci\u00f3 de l\u00edpids a les fases inicials de la malaltia.<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519,340],"tags":[],"class_list":["post-6625","post","type-post","status-publish","format-standard","hentry","category-investigacio","category-sense-categoria"],"acf":[],"yoast_head":"\nIdentificat un nou biomarcador per predir i diagnosticar la malaltia del fetge gras no alcoh\u00f2lic - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/nou-biomarcador-diagnosticar-malaltia-fetge-gras-no-alcoholic\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identificat un nou biomarcador per predir i diagnosticar la malaltia del fetge gras no alcoh\u00f2lic - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"D\u2019esquerra a dreta: Les investigadores de l\u2019estudi del Grup DIAMET del IISPV Victoria Ceperuelo Mallafr\u00e9, Anna Marsal Beltran i Sonia Fern\u00e1ndez-Veledo. Un estudi liderat des de l\u2019Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), de Tarragona, i publicat a la prestigiosa revista cient\u00edfica Metabolism ha perm\u00e8s identificar el succinat com a nou biomarcador present a la sang per predir la malaltia del fetge gras no alcoh\u00f2lic i per confirmar-ne el seu diagn\u00f2stic. 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