{"id":6325,"date":"2023-05-04T10:59:20","date_gmt":"2023-05-04T09:59:20","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=6325"},"modified":"2023-05-09T10:55:20","modified_gmt":"2023-05-09T09:55:20","slug":"cnio-caixaresearch-frontiers-meeting-organitzacio-i-estabilitat-del-genoma","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/cnio-caixaresearch-frontiers-meeting-organitzacio-i-estabilitat-del-genoma\/","title":{"rendered":"CNIO-CaixaResearch Frontiers Meeting: \u2018Genome Organisation and Stability’"},"content":{"rendered":"

\"\"<\/span><\/p>\n

Els dies 22 i 23 de maig se celebrar\u00e0 el congr\u00e9s CNIO-CaixaResearch Frontiers Meeting, amb el t\u00edtol <\/span>\u00abGenome Organisation and Stability\u00bb<\/span><\/a>. El congr\u00e9s girar\u00e0 a l\u2019entorn dels \u00faltims descobriments sobre l\u2019estructura tridimensional del genoma i la repercussi\u00f3 que t\u00e9 en l\u2019estabilitat gen\u00f2mica. Segons estudis recents, els errors en l\u2019estructura del genoma estan relacionats amb el c\u00e0ncer.<\/span><\/p>\n

Les c\u00e8l\u00b7lules han desenvolupat la capacitat de plegar i organitzar el seu ADN a la perfecci\u00f3. Cada c\u00e8l\u00b7lula del nostre cos cont\u00e9 m\u00e9s de dos metres d\u2019ADN. Si aquestes mol\u00e8cules simplement es comprimissin formant una bola, l\u2019embull resultant seria m\u00e9s gran que la c\u00e8l\u00b7lula. Tanmateix, les nostres c\u00e8l\u00b7lules saben empaquetar h\u00e0bilment aquest material gen\u00e8tic en el nucli cel\u00b7lular.<\/span><\/p>\n

L\u2019estudi del plegament de l\u2019ADN ha suscitat un gran inter\u00e8s aquests \u00faltims anys. Segons els \u00faltims descobriments, la forma tridimensional de l\u2019ADN determina com s\u2019expressen els gens, ja que entren en contacte zones distants de la mol\u00e8cula.<\/span><\/p>\n

El congr\u00e9s reunir\u00e0 vint experts internacionals en aquest camp d\u2019investigaci\u00f3 per debatre sobre els \u00faltims descobriments sobre l\u2019estructura tridimensional del genoma i la repercussi\u00f3 que t\u00e9 en l\u2019estabilitat gen\u00f2mica. A m\u00e9s, comprendre el plegament de l\u2019ADN contribuir\u00e0 a identificar les zones m\u00e9s fr\u00e0gils i inestables del genoma, propenses a patir reordenaments del material gen\u00e8tic que augmenten la inestabilitat del genoma i condueixen a l\u2019aparici\u00f3 d\u2019errors en la c\u00e8l\u00b7lula. Recentment s\u2019ha descobert que aquests processos estan directament relacionats amb el c\u00e0ncer.<\/span><\/p>\n

\"\"<\/p>\n

Simulaci\u00f3 de l\u2019estructura dels cromosomes en 3D. \/ Fotografia: M. Di Stefano i C. Micheletti, SISSA.<\/span><\/i><\/p>\n

\u00abEl plegament tridimensional [de l\u2019ADN] en el nucli cel\u00b7lular determina com les c\u00e8l\u00b7lules llegeixen, interpreten i mantenen la informaci\u00f3 del genoma. El seu estudi ha suscitat un gran inter\u00e8s en els \u00faltims anys\u00bb, assenyalen els organitzadors del congr\u00e9s, els investigadors del CNIO Felipe Cort\u00e9s, Ana Losada i \u00d3scar Fern\u00e1ndez-Capetillo, i Andre Nussenzweig, de l\u2019Institut Nacional del C\u00e0ncer dels Estats Units.<\/span><\/p>\n

\u00abL\u2019exemple m\u00e9s il\u00b7lustratiu \u00e9s potser la regulaci\u00f3 de l\u2019expressi\u00f3 dels gens, que ara \u00e9s inconcebible entendre sense tenir en compte com est\u00e0 organitzat estructuralment el genoma\u00bb, afirmen. \u00abLes connexions entre l\u2019organitzaci\u00f3 tridimensional del genoma i els processos de senyalitzaci\u00f3 i reparaci\u00f3 dels danys a l\u2019ADN, tot i que s\u2019han descobert fa poc, estan demostrant que s\u00f3n fonamentals per comprendre les fonts end\u00f2genes de les ruptures d\u2019ADN i els reordenaments cromos\u00f2mics que donen lloc a l\u2019aparici\u00f3 i la progressi\u00f3 del c\u00e0ncer. El congr\u00e9s reunir\u00e0 destacats investigadors de tot el m\u00f3n, experts en tots dos camps \u2014l\u2019organitzaci\u00f3 del genoma en 3D i la resposta als danys en l\u2019ADN\u2014 amb la finalitat de crear un marc ideal per bastir ponts entre aquests dos aspectes fonamentals de la din\u00e0mica del genoma.\u00bb<\/span><\/p>\n

En conjunt, el congr\u00e9s vol superar la bretxa que hi ha entre l\u2019organitzaci\u00f3 tridimensional del genoma i la resposta als danys en l\u2019ADN, proporcionant un marc ideal perqu\u00e8 destacats investigadors de tot el m\u00f3n, experts en tots dos camps, es reuneixin i comparteixin els seus coneixements.<\/span><\/p>\n

Aquest article \u00e9s una adaptaci\u00f3 d\u2019un <\/i><\/b>article<\/i><\/b><\/a> publicat originalment al lloc web del CNIO.<\/i><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/p>\n

Els dies 22 i 23 de maig se celebrar\u00e0 el congr\u00e9s CNIO-CaixaResearch Frontiers Meeting, amb el t\u00edtol \u00abGenome Organisation and Stability\u00bb<\/a>. El congr\u00e9s girar\u00e0 a l\u2019entorn dels \u00faltims descobriments sobre l\u2019estructura tridimensional del genoma i la repercussi\u00f3 que t\u00e9 en l\u2019estabilitat gen\u00f2mica. Segons estudis recents, els errors en l\u2019estructura del genoma estan relacionats amb el c\u00e0ncer.<\/p>\n

Les c\u00e8l\u00b7lules han desenvolupat la capacitat de plegar i organitzar el seu ADN a la perfecci\u00f3. Cada c\u00e8l\u00b7lula del nostre cos cont\u00e9 m\u00e9s de dos metres d\u2019ADN. Si aquestes mol\u00e8cules simplement es comprimissin formant una bola, l\u2019embull resultant seria m\u00e9s gran que la c\u00e8l\u00b7lula. Tanmateix, les nostres c\u00e8l\u00b7lules saben empaquetar h\u00e0bilment aquest material gen\u00e8tic en el nucli cel\u00b7lular.<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[520],"tags":[501],"class_list":["post-6325","post","type-post","status-publish","format-standard","hentry","category-divulgacio-cientifica","tag-cancer-ca"],"acf":[],"yoast_head":"\nCNIO-CaixaResearch Frontiers Meeting: \u2018Genome Organisation and Stability' - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/cnio-caixaresearch-frontiers-meeting-organitzacio-i-estabilitat-del-genoma\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CNIO-CaixaResearch Frontiers Meeting: \u2018Genome Organisation and Stability' - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Els dies 22 i 23 de maig se celebrar\u00e0 el congr\u00e9s CNIO-CaixaResearch Frontiers Meeting, amb el t\u00edtol \u00abGenome Organisation and Stability\u00bb. 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