Universitat Pompeu Fabra<\/a> en un projecte de recerca innovador gr\u00e0cies al suport de l’Obra Social “la Caixa”.<\/p>\n \u00c9s possible regular la glic\u00e8mia fora del p\u00e0ncrees?<\/strong><\/p>\n Molts tipus de patologies s’originen en la disfunci\u00f3 d’un \u00f2rgan o teixit que es tradueix en el desequilibri d’algun dels processos de regulaci\u00f3 essencials per a l’organisme. La diabetis tipus 1 n’\u00e9s un exemple paradigm\u00e0tic. El mal funcionament del p\u00e0ncrees t\u00e9 com a resultat un desequilibri hormonal entre insulina i glucag\u00f3 que porta a la regulaci\u00f3 incorrecta dels nivells de glucosa a la sang. De fet, el p\u00e0ncrees deixa de produir insulina com a conseq\u00fc\u00e8ncia de la p\u00e8rdua de les c\u00e8l\u00b7lules beta, productores d’aquesta hormona. Actualment, els investigadors de la Universitat Pompeu Fabra, en col\u00b7laboraci\u00f3 amb el CIDI, explorem la possibilitat de reprogramar altres c\u00e8l\u00b7lules de l’organisme per tal que puguin dur a terme les funcions que correspondrien al p\u00e0ncrees afectat<\/strong>. Aquesta reprogramaci\u00f3 cel\u00b7lular s’aconsegueix mitjan\u00e7ant l’\u00fas de t\u00e8cniques d’enginyeria gen\u00e8tica, introduint nous gens a les c\u00e8l\u00b7lules o modificant els ja existents.<\/p>\n ![\"\"](\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2020\/04\/ca\/DSC_7318-2.jpeg\")
<\/p>\n
L’objectiu \u00e9s la creaci\u00f3 d’uns circuits gen\u00e8tics nous que, un cop introdu\u00efts en c\u00e8l\u00b7lules no pancre\u00e0tiques, facin que aquestes siguin capaces de regular els nivells de glucosa de l’organisme. Per aconseguir aix\u00f2 s’est\u00e0 explorant la creaci\u00f3 d’un sistema de detecci\u00f3 dels nivells de glucosa capa\u00e7 de distingir entre tres r\u00e8gims: els nivells de baixa glucosa o hipogluc\u00e8mia, els nivells d’alta glucosa o hipergluc\u00e8mia i els nivells fisiol\u00f2gicament \u00f2ptims o normogluc\u00e8mia. Aix\u00f2 es pot aconseguir aprofitant certs mecanismes propis de les c\u00e8l\u00b7lules que, de manera natural, ja activen l’expressi\u00f3 d’uns gens o d’uns altres depenent dels nivells de glucosa.<\/p>\n
Fent l’adequada enginyeria gen\u00e8tica podem modificar aquests sistemes naturals i introduir entre aquests gens activats per glucosa els gens de la insulina i del glucag\u00f3. D’aquesta manera s’aconsegueix que, a m\u00e9s de les seves funcions normals, aquestes c\u00e8l\u00b7lules secretin insulina o glucag\u00f3 en funci\u00f3 dels nivells de glucosa a la sang. Actualment ja s’han creat diferents tipus cel\u00b7lulars no pancre\u00e0tics amb aquests nous circuits gen\u00e8tics i s’est\u00e0 en la fase d’analitzar com responen aquestes c\u00e8l\u00b7lules, en termes de producci\u00f3 d’insulina i glucag\u00f3, sota condicions de glucosa diverses.<\/p>\n
Malgrat que encara falta molt de temps perqu\u00e8 aquests nous aven\u00e7os puguin ser aplicables, les possibilitats que les noves t\u00e8cniques de manipulaci\u00f3 gen\u00e8tica ens ofereixen semblen molt prometedores.<\/p>\n<\/p><\/div>\n
<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n
Post de Rub\u00e9n D\u00edaz, director del CIDI Sant Joan de D\u00e9u, i Javier Mac\u00eda, investigador del Departament de Ci\u00e8ncies Experimentals i de la Salut de la Universitat Pompeu Fabra.<\/p>\n
Des del Centre per a la Innovaci\u00f3 de la Diabetis Infantil Sant Joan de D\u00e9u (CIDI)<\/a>, gr\u00e0cies a la col\u00b7laboraci\u00f3 de l’Obra Social “la Caixa”<\/a>, treballem per incrementar la conscienciaci\u00f3 social sobre la diabetis tipus 1 i per millorar la qualitat de vida de les persones afectades per aquesta malaltia, per\u00f2 sobretot apostem fermament per la recerca per poder millorar el tractament i arribar a trobar-ne la cura.<\/p>\n ![\"\"](\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2020\/04\/ca\/DSC_6680-2.jpeg\")
<\/p>\n
Amb aquest objectiu, el CIDI,<\/p>\n","protected":false},"author":1,"featured_media":2635,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519],"tags":[],"class_list":["post-2423","post","type-post","status-publish","format-standard","hentry","category-investigacio"],"acf":[],"yoast_head":"\n
La recerca, l'\u00fanica via per aproximar-nos a una cura de la diabetis infantil - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/la-recerca-lunica-via-per-aproximar-nos-a-una-cura-de-la-diabetis-infantil\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La recerca, l'\u00fanica via per aproximar-nos a una cura de la diabetis infantil - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Post de Rub\u00e9n D\u00edaz, director del CIDI Sant Joan de D\u00e9u, i Javier Mac\u00eda, investigador del Departament de Ci\u00e8ncies Experimentals i de la Salut de la Universitat Pompeu Fabra. Des del Centre per a la Innovaci\u00f3 de la Diabetis Infantil Sant Joan de D\u00e9u (CIDI), gr\u00e0cies a la col\u00b7laboraci\u00f3 de l’Obra Social “la Caixa”, treballem per incrementar la conscienciaci\u00f3 social sobre la diabetis tipus 1 i per millorar la qualitat de vida de les persones afectades per aquesta malaltia, per\u00f2 sobretot apostem fermament per la recerca per poder millorar el tractament i arribar a trobar-ne la cura. 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