{"id":2143,"date":"2018-05-25T00:00:00","date_gmt":"2018-05-25T00:00:00","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=2143"},"modified":"2020-05-05T08:32:03","modified_gmt":"2020-05-05T08:32:03","slug":"el-projecte-grace-identifica-tres-categories-diferents-de-gens-involucrats-en-la-malaltia-dalzheimer","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/el-projecte-grace-identifica-tres-categories-diferents-de-gens-involucrats-en-la-malaltia-dalzheimer\/","title":{"rendered":"El projecte GR@ACE identifica tres categories diferents de gens involucrats en la malaltia d\u2019Alzheimer"},"content":{"rendered":"

<\/p>\n

\n

Post de l\u2019Obra Social \u201cla Caixa\u201d<\/strong><\/p>\n

Al voltant de 35 milions de persones arreu del m\u00f3n pateixen actualment la malaltia d\u2019Alzheimer. Es calcula que per a l\u2019any 2050, aquesta xifra augmentar\u00e0 fins als 135 milions. Tenint en compte que l\u2019\u00faltim tractament per a aquesta malaltia va apar\u00e8ixer el 2003 i que, des d\u2019aleshores, m\u00e9s del 99 % dels assajos cl\u00ednics ha fracassat, els aven\u00e7os en aquesta mena de dem\u00e8ncia s\u00f3n m\u00e9s que benvinguts.<\/p>\n

Liderat per la Fundaci\u00f3 ACE<\/a>, amb el suport de la Fundaci\u00f3 Banc\u00e0ria \u201dla Caixa\u201d<\/a> i Grifols<\/a>, el projecte Genomic Research At Fundaci\u00f3 ACE<\/em> (GR@ACE) va presentar el 23 de maig els primers resultats de la investigaci\u00f3. D\u2019acord amb l\u2019estudi fet sobre 7.400 genomes, tant de pacients com de persones sanes, els gens involucrats en aquesta malaltia es poden classificar en tres categories diferents: els gens vinculats a la neuroinflamaci\u00f3; els gens relacionats amb la neurodegeneraci\u00f3 i l\u2019envelliment, i, finalment, els gens que provoquen un dany predominantment vascular.<\/p>\n

\"\"
D\u2019esquerra a dreta: Agust\u00edn Ruiz, de la Fundaci\u00f3 ACE i investigador principal de GR@ACE; V\u00edctor Gr\u00edfols, president de Grifols; Merc\u00e8 Boada, directora m\u00e8dica de la Fundaci\u00f3 ACE; \u00c0ngel Font, director de l\u2019\u00c0rea de Recerca i Estrat\u00e8gia de la Fundaci\u00f3 Banc\u00e0ria \u201dla Caixa\u201d, i Llu\u00eds T\u00e1rraga, psic\u00f2leg cl\u00ednic i director de la Fundaci\u00f3 ACE. Imatge: Fundaci\u00f3 ACE. Berta Alarc\u00f3.<\/span><\/p>\n

Presentat durant el 2nd Symposium on Dementia Genetics<\/a>, la troballa ha estat possible gr\u00e0cies a la gran quantitat de mostres que s\u2019han analitzat i a la seva qualitat diagn\u00f2stica. \u201cLa poblaci\u00f3 espanyola \u00e9s molt homog\u00e8nia des del punt de vista gen\u00e8tic, la qual cosa ens dona molt\u00edssim avantatge per identificar gens relacionats amb la malaltia d\u2019Alzheimer, comenta l\u2019Agust\u00edn Ruiz, investigador principal del projecte GR@ACE. \u201cAnalitzant les subtils difer\u00e8ncies presents en cada mostra hem pogut identificar les tres categories de gens involucrats en la malaltia\u201d, afegeix l\u2019especialista.<\/p>\n

Si es confirmen les tres categories, les estrat\u00e8gies terap\u00e8utiques per fer front a la malaltia d\u2019Alzheimer es dirigiran cap a les ter\u00e0pies combinades. Segons Ruiz, \u201cpoder identificar els factors de risc ens permetr\u00e0 desenvolupar ter\u00e0pies per a cada component implicat. Aix\u00f2 facilitar\u00e0 el disseny de ter\u00e0pies personalitzades en funci\u00f3 de la c\u00e0rrega de cada component que tingui cada persona\u201d. I hi afegeix: \u201cSi es confirmen els resultats i podem classificar correctament tots els gens de la malaltia d\u2019Alzheimer, probablement els tractaments seran diferents per a cada pacient\u201d.<\/p>\n

\"\"
Agust\u00edn Ruiz durant la presentaci\u00f3 al 2n Symposium on Dementia Genetics<\/em>. Imatge: Fundaci\u00f3 ACE. Berta Alarc\u00f3.<\/span><\/p>\n

El conjunt de genomes analitzat pel projecte GR@ACE se situa com una de les mostres gen\u00e8tiques m\u00e9s grans i homog\u00e8nies del m\u00f3n. En la segona fase del projecte es descodificaran 11.000 genomes m\u00e9s, que, units als m\u00e9s de 7.000 que s\u2019han analitzat en la primera fase, el convertiran en un dels rastrejos complets del genoma de la malaltia d\u2019Alzheimer m\u00e9s grans del m\u00f3n.<\/p>\n<\/p><\/div>\n

<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n

Post de l\u2019Obra Social \u201cla Caixa\u201d<\/p>\n

Al voltant de 35 milions de persones arreu del m\u00f3n pateixen actualment la malaltia d\u2019Alzheimer. Es calcula que per a l\u2019any 2050, aquesta xifra augmentar\u00e0 fins als 135 milions. Tenint en compte que l\u2019\u00faltim tractament per a aquesta malaltia va apar\u00e8ixer el 2003 i que, des d\u2019aleshores, m\u00e9s del 99 % dels assajos cl\u00ednics ha fracassat, els aven\u00e7os en aquesta mena de dem\u00e8ncia s\u00f3n m\u00e9s que benvinguts.<\/p>\n

Liderat per la Fundaci\u00f3 ACE<\/a>, amb el suport de la Fundaci\u00f3 Banc\u00e0ria \u201dla Caixa\u201d<\/a> i Grifols<\/a>, el projecte Genomic Research At Fundaci\u00f3 ACE<\/em> (GR@ACE) va presentar el 23 de maig els primers resultats de la investigaci\u00f3.<\/p>\n","protected":false},"author":1,"featured_media":3003,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519],"tags":[75,443,20,365],"class_list":["post-2143","post","type-post","status-publish","format-standard","hentry","category-investigacio","tag-alzheimer","tag-fundacio-ace","tag-genetica","tag-recerca"],"acf":[],"yoast_head":"\nEl projecte GR@ACE identifica tres categories diferents de gens involucrats en la malaltia d\u2019Alzheimer - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/el-projecte-grace-identifica-tres-categories-diferents-de-gens-involucrats-en-la-malaltia-dalzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El projecte GR@ACE identifica tres categories diferents de gens involucrats en la malaltia d\u2019Alzheimer - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Post de l\u2019Obra Social \u201cla Caixa\u201d Al voltant de 35 milions de persones arreu del m\u00f3n pateixen actualment la malaltia d\u2019Alzheimer. Es calcula que per a l\u2019any 2050, aquesta xifra augmentar\u00e0 fins als 135 milions. Tenint en compte que l\u2019\u00faltim tractament per a aquesta malaltia va apar\u00e8ixer el 2003 i que, des d\u2019aleshores, m\u00e9s del 99 % dels assajos cl\u00ednics ha fracassat, els aven\u00e7os en aquesta mena de dem\u00e8ncia s\u00f3n m\u00e9s que benvinguts. 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