{"id":2141,"date":"2018-05-30T00:00:00","date_gmt":"2018-05-30T00:00:00","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=2141"},"modified":"2020-05-05T08:32:02","modified_gmt":"2020-05-05T08:32:02","slug":"cap-a-un-nou-tractament-per-a-lesclerosi-multiple","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/cap-a-un-nou-tractament-per-a-lesclerosi-multiple\/","title":{"rendered":"Cap a un nou tractament per a l\u2019esclerosi m\u00faltiple"},"content":{"rendered":"

<\/p>\n

\n

Post de l’Obra Social “la Caixa”<\/strong><\/p>\n

En aquest moment, m\u00e9s de 2,5 milions de persones al m\u00f3n viuen amb esclerosi m\u00faltiple (EM), una malaltia degenerativa i autoimmunit\u00e0ria que encara no t\u00e9 cura. Per impulsar la recerca de noves ter\u00e0pies, la Fundaci\u00f3 Banc\u00e0ria \u201dla Caixa\u201d<\/a> i la Fundaci\u00f3 GAEM<\/a> donen suport al projecte Ter\u00e0pia cel\u00b7lular de toler\u00e0ncia immune<\/strong>, que desenvolupen cient\u00edfics de l\u2019IDIBAPS<\/a> (Institut d\u2019Investigacions M\u00e8diques Agust\u00ed Pi i Sunyer) i de l\u2019Hospital Cl\u00ednic de Barcelona<\/a>.<\/p>\n

En l\u2019EM, els gl\u00f2buls blancs del sistema immunitari ataquen per error les c\u00e8l\u00b7lules sanes del sistema nervi\u00f3s. En concret, destrueixen la mielina, un material protector que recobreix els nervis del cervell, la medul\u00b7la espinal i el nervi \u00f2ptic. Sense mielina, el cervell no aconsegueix comunicar-se correctament amb les altres parts del cos, i aix\u00f2 causa s\u00edmptomes com ara la p\u00e8rdua de for\u00e7a muscular, problemes d\u2019equilibri o visi\u00f3 borrosa.<\/p>\n

La ter\u00e0pia cel\u00b7lular de toler\u00e0ncia immune<\/strong> \u00e9s un tractament pioner en el qual els cient\u00edfics a\u00efllen un tipus de gl\u00f2buls blancs (les c\u00e8l\u00b7lules dendr\u00edtiques) de la sang dels pacients i els fan madurar artificialment al laboratori perqu\u00e8 no detectin la mielina com una amena\u00e7a. Despr\u00e9s, s\u2019administren de nou al pacient amb l\u2019objectiu de regular i reeducar el seu sistema immunitari perqu\u00e8 deixi d\u2019atacar la mielina i, aix\u00ed, es pugui frenar la progressi\u00f3 de la malaltia.<\/p>\n

Un dels avantatges de la ter\u00e0pia cel\u00b7lular \u00e9s que les c\u00e8l\u00b7lules tolerants es preparen a partir de la sang del propi pacient, fet que evita un possible rebuig del tractament. Fins ara, s\u2019ha provat la seguretat de la ter\u00e0pia cel\u00b7lular de toler\u00e0ncia immune amb pacients d\u2019EM durant la fase cl\u00ednica 1b, en la qual s\u2019han detectat canvis en determinats marcadors bioqu\u00edmics, relacionats amb una acci\u00f3 inflamat\u00f2ria. Per tal de confirmar resultats, enguany s\u2019est\u00e0 duent a terme una ampliaci\u00f3 amb 10 pacients m\u00e9s. Una vegada acabi la fase 1b, comen\u00e7ar\u00e0 la fase cl\u00ednica 2, que permetr\u00e0 determinar l\u2019efic\u00e0cia del tractament.<\/p>\n

\"\"<\/a>
Font: Fundaci\u00f3 GAEM<\/a>.<\/span><\/p>\n<\/p><\/div>\n

<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n

Post de l’Obra Social “la Caixa”<\/p>\n

En aquest moment, m\u00e9s de 2,5 milions de persones al m\u00f3n viuen amb esclerosi m\u00faltiple (EM), una malaltia degenerativa i autoimmunit\u00e0ria que encara no t\u00e9 cura. Per impulsar la recerca de noves ter\u00e0pies, la Fundaci\u00f3 Banc\u00e0ria \u201dla Caixa\u201d<\/a> i la Fundaci\u00f3 GAEM<\/a> donen suport al projecte Ter\u00e0pia cel\u00b7lular de toler\u00e0ncia immune, que desenvolupen cient\u00edfics de l\u2019IDIBAPS<\/a> (Institut d\u2019Investigacions M\u00e8diques Agust\u00ed Pi i Sunyer) i de l\u2019Hospital Cl\u00ednic de Barcelona<\/a>.<\/p>\n

En l\u2019EM, els gl\u00f2buls blancs del sistema immunitari ataquen per error les c\u00e8l\u00b7lules sanes del sistema nervi\u00f3s. En concret, destrueixen la mielina, un material protector que recobreix els nervis del cervell,<\/p>\n","protected":false},"author":1,"featured_media":3015,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519],"tags":[466,467,365],"class_list":["post-2141","post","type-post","status-publish","format-standard","hentry","category-investigacio","tag-esclerosi-multiple","tag-fundacio-gaem","tag-recerca"],"acf":[],"yoast_head":"\nCap a un nou tractament per a l\u2019esclerosi m\u00faltiple - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/cap-a-un-nou-tractament-per-a-lesclerosi-multiple\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cap a un nou tractament per a l\u2019esclerosi m\u00faltiple - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Post de l’Obra Social “la Caixa” En aquest moment, m\u00e9s de 2,5 milions de persones al m\u00f3n viuen amb esclerosi m\u00faltiple (EM), una malaltia degenerativa i autoimmunit\u00e0ria que encara no t\u00e9 cura. Per impulsar la recerca de noves ter\u00e0pies, la Fundaci\u00f3 Banc\u00e0ria \u201dla Caixa\u201d i la Fundaci\u00f3 GAEM donen suport al projecte Ter\u00e0pia cel\u00b7lular de toler\u00e0ncia immune, que desenvolupen cient\u00edfics de l\u2019IDIBAPS (Institut d\u2019Investigacions M\u00e8diques Agust\u00ed Pi i Sunyer) i de l\u2019Hospital Cl\u00ednic de Barcelona. En l\u2019EM, els gl\u00f2buls blancs del sistema immunitari ataquen per error les c\u00e8l\u00b7lules sanes del sistema nervi\u00f3s. 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