{"id":2115,"date":"2018-07-19T00:00:00","date_gmt":"2018-07-19T00:00:00","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=2115"},"modified":"2020-05-05T08:31:51","modified_gmt":"2020-05-05T08:31:51","slug":"la-immunoterapia-una-estrategia-esperancadora-en-la-lluita-contra-el-cancer","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/la-immunoterapia-una-estrategia-esperancadora-en-la-lluita-contra-el-cancer\/","title":{"rendered":"La immunoter\u00e0pia, una estrat\u00e8gia esperan\u00e7adora en la lluita contra el c\u00e0ncer"},"content":{"rendered":"

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\"CNIO<\/p>\n

Combatre el c\u00e0ncer atacant els mecanismes de defensa del propi organisme. Aquesta \u00e9s l’estrat\u00e8gia que segueix la immunoter\u00e0pia, un tractament que es basa en l’estimulaci\u00f3 del sistema immunitari per lluitar contra el desenvolupament d’un tumor. Els bons resultats que aquest tractament est\u00e0 donant en tumors molt agressius han portat la immunoter\u00e0pia a ser protagonista de l’\u00faltim congr\u00e9s del cicle CNIO \u2013 “la Caixa” Frontiers Meetings, titulat Frontiers in Immunomodulation and Cancer Therapy<\/a>. L’esdeveniment, que es va celebrar la setmana passada, va reunir els millors experts del m\u00f3n en la relaci\u00f3 entre sistema immunitari i c\u00e0ncer, que van aprofitar l’ocasi\u00f3 per compartir els reptes a qu\u00e8 s’enfronten en les seves investigacions.<\/p>\n

Els efectes secundaris de la immunoter\u00e0pia o la resist\u00e8ncia que ofereixen tumors a aquest tractament van ser alguns dels temes que es van plantejar. “Perqu\u00e8 la immunoter\u00e0pia sigui efectiva, s\u2019han de produir m\u00faltiples processos, des de recon\u00e8ixer les c\u00e8l\u00b7lules tumorals fins atacar-les”, va explicar Marisol Soengas, investigadora del Grup de Melanoma<\/a> del Centre Nacional d’Investigacions Oncol\u00f2giques (CNIO<\/a>). “La fallada en la resposta a la immunoter\u00e0pia es pot produir per un bloqueig en qualsevol d’aquests processos”.<\/p>\n

A m\u00e9s, alguns pacients no responen a la ter\u00e0pia. \u201cEls mecanismes de resist\u00e8ncia a la immunoter\u00e0pia s\u00f3n diversos i inclouen tant factors gen\u00e8tics com mediambientals\u201d, afirma Soengas. Entre els factors gen\u00e8tics es troben unes prote\u00efnes adre\u00e7ades a limitar l’activaci\u00f3 excessiva del sistema immunitari, els anomenats \u2018punts de control immunitari\u2019. Actualment aquestes prote\u00efnes s\u00f3n la diana m\u00e9s estesa i reeixida de la immunoter\u00e0pia, ja que inhibint aquests punts de control es pot activar la resposta antitumoral.<\/p>\n

La immunoter\u00e0pia est\u00e0 resultant especialment efectiva en tumors com el melanoma, un camp en el qual Soengas \u00e9s experta. \u201cAls assaigs cl\u00ednics s’ha aconseguit eliminar el desenvolupament tumoral, almenys a curt termini, fins al 70 % dels pacients.\u201d Una de les raons de l’\u00e8xit \u00e9s l’acumulaci\u00f3 d’un gran nombre de mutacions en les c\u00e8l\u00b7lules de melanoma, que serveixen com a punt de reconeixement per al sistema immunitari, i que aconsegueixen que els inhibidors de punt de control actu\u00efn de manera molt efica\u00e7.<\/p>\n

Al congr\u00e9s es van presentar nous biomarcadors i possibles dianes terap\u00e8utiques. Tamb\u00e9 es van descriure nous models experimentals i dades molt innovadores sobre factors que influeixen en la resposta a tractaments en assaig cl\u00ednic, com ara la mateixa poblaci\u00f3 bacteriana dels pacients.\u00a0Malgrat els grans reptes que queden per resoldre, la immunoter\u00e0pia \u00e9s una estrat\u00e8gia molt esperan\u00e7adora en la lluita contra el c\u00e0ncer. Tot i que, tal com van concloure els experts, cal seguir investigant per concretar qui es pot beneficiar del tractament i sobre quins tumors \u00e9s m\u00e9s efica\u00e7.<\/p>\n<\/p><\/div>\n

<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n

\"CNIO<\/p>\n

Combatre el c\u00e0ncer atacant els mecanismes de defensa del propi organisme. Aquesta \u00e9s l’estrat\u00e8gia que segueix la immunoter\u00e0pia, un tractament que es basa en l’estimulaci\u00f3 del sistema immunitari per lluitar contra el desenvolupament d’un tumor. Els bons resultats que aquest tractament est\u00e0 donant en tumors molt agressius han portat la immunoter\u00e0pia a ser protagonista de l’\u00faltim congr\u00e9s del cicle CNIO \u2013 “la Caixa” Frontiers Meetings, titulat Frontiers in Immunomodulation and Cancer Therapy<\/a>. L’esdeveniment, que es va celebrar la setmana passada, va reunir els millors experts del m\u00f3n en la relaci\u00f3 entre sistema immunitari i c\u00e0ncer, que van aprofitar l’ocasi\u00f3 per compartir els reptes a qu\u00e8 s’enfronten en les seves investigacions.<\/p>\n","protected":false},"author":1,"featured_media":2997,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519],"tags":[36,216,454,438,397,218,365],"class_list":["post-2115","post","type-post","status-publish","format-standard","hentry","category-investigacio","tag-cancer","tag-cnio","tag-congres","tag-immunologia","tag-immunoterapia","tag-melanoma","tag-recerca"],"acf":[],"yoast_head":"\nLa immunoter\u00e0pia, una estrat\u00e8gia esperan\u00e7adora en la lluita contra el c\u00e0ncer - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/la-immunoterapia-una-estrategia-esperancadora-en-la-lluita-contra-el-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La immunoter\u00e0pia, una estrat\u00e8gia esperan\u00e7adora en la lluita contra el c\u00e0ncer - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Combatre el c\u00e0ncer atacant els mecanismes de defensa del propi organisme. Aquesta \u00e9s l’estrat\u00e8gia que segueix la immunoter\u00e0pia, un tractament que es basa en l’estimulaci\u00f3 del sistema immunitari per lluitar contra el desenvolupament d’un tumor. Els bons resultats que aquest tractament est\u00e0 donant en tumors molt agressius han portat la immunoter\u00e0pia a ser protagonista de l’\u00faltim congr\u00e9s del cicle CNIO \u2013 “la Caixa” Frontiers Meetings, titulat Frontiers in Immunomodulation and Cancer Therapy. L’esdeveniment, que es va celebrar la setmana passada, va reunir els millors experts del m\u00f3n en la relaci\u00f3 entre sistema immunitari i c\u00e0ncer, que van aprofitar l’ocasi\u00f3 per compartir els reptes a qu\u00e8 s’enfronten en les seves investigacions.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blog.caixaresearch.org\/ca\/la-immunoterapia-una-estrategia-esperancadora-en-la-lluita-contra-el-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"article:published_time\" content=\"2018-07-19T00:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-05-05T08:31:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2020\/04\/ca\/CNIO+-+la+Caixa+Frontiers+Meeting.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"400\" \/>\n\t<meta property=\"og:image:height\" content=\"157\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"La Caixa\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"La Caixa\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/blog.caixaresearch.org\/ca\/la-immunoterapia-una-estrategia-esperancadora-en-la-lluita-contra-el-cancer\/\",\"url\":\"https:\/\/blog.caixaresearch.org\/ca\/la-immunoterapia-una-estrategia-esperancadora-en-la-lluita-contra-el-cancer\/\",\"name\":\"La immunoter\u00e0pia, una estrat\u00e8gia esperan\u00e7adora en la lluita contra el c\u00e0ncer - 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