La revoluci\u00f3 de la immunoter\u00e0pia per al c\u00e0ncer de pulm\u00f3 - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/la-revolucio-de-la-immunoterapia-per-al-cancer-de-pulmo\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La revoluci\u00f3 de la immunoter\u00e0pia per al c\u00e0ncer de pulm\u00f3 - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Post de l’Obra Social “la Caixa” Immunoter\u00e0pia. f. Med. Ter\u00e0pia basada en l\u2019\u00fas de subst\u00e0ncies per estimular o reprimir el sistema immune i ajudar el cos a combatre el c\u00e0ncer, infeccions i altres malalties. Visi\u00f3 microsc\u00f2pica d\u2019un c\u00e0ncer de pulm\u00f3 on les c\u00e8l\u00b7lules immunes (marr\u00f3) s\u2019infiltren en les c\u00e8l\u00b7lules tumorals (blau). La immunoter\u00e0pia per al c\u00e0ncer \u00e9s una cursa cient\u00edfica de fons que fa poc s\u2019ha desmarcat de l\u2019escamot a velocitat de sprint. Els cient\u00edfics fa d\u00e8cades que busquen la f\u00f3rmula per aconseguir que determinats c\u00e0ncers no passin desapercebuts pel sistema immune i aix\u00ed els pugui atacar de manera m\u00e9s efica\u00e7. 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Post de l’Obra Social “la Caixa”<\/strong><\/p>\n

Immunoter\u00e0pia. f. Med.<\/strong> Ter\u00e0pia basada en l\u2019\u00fas de subst\u00e0ncies per estimular o reprimir el sistema immune i ajudar el cos a combatre el c\u00e0ncer, infeccions i altres malalties.<\/p>\n

$\"\"$
Visi\u00f3 microsc\u00f2pica d\u2019un c\u00e0ncer de pulm\u00f3 on les c\u00e8l\u00b7lules immunes (marr\u00f3) s\u2019infiltren en les c\u00e8l\u00b7lules tumorals (blau).<\/span><\/p>\n

Un dels c\u00e0ncers per als quals la immunoter\u00e0pia resulta efectiva \u00e9s el c\u00e0ncer de pulm\u00f3 no microc\u00edtic, la forma m\u00e9s prevalent d\u2019aquest c\u00e0ncer. Cada any, durant la segona setmana de setembre, se celebra la Setmana Europea del C\u00e0ncer de Pulm\u00f3, que persegueix conscienciar la poblaci\u00f3 sobre la prevenci\u00f3, la detecci\u00f3, els s\u00edmptomes i les conseq\u00fc\u00e8ncies d\u2019aquesta malaltia. Des de la Fundaci\u00f3 Banc\u00e0ria \u201dla Caixa\u201d, ens afegim a aquesta iniciativa impulsant la recerca de ter\u00e0pies cada vegada m\u00e9s personalitzades per al c\u00e0ncer de pulm\u00f3.<\/p>\n

No tots els pacients responen<\/strong><\/p>\n

Fa poc, un grup d\u2019investigadors liderats per Manel Esteller, de l\u2019Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge<\/a> (IDIBELL), han descobert una empremta epigen\u00e8tica que prediu la resposta de la immunoter\u00e0pia en el c\u00e0ncer de pulm\u00f3.<\/p>\n

\u201cEls senyals epigen\u00e8tics, com la metilaci\u00f3 de l\u2019ADN, actuen com a interruptors de l\u2019electricidad que enc\u00e9n o apaguem milers dels nostres gens. Per tant, pensem que tamb\u00e9 haurien de participar en els programes que la c\u00e8l\u00b7lula tumoral fa servir per escapar-se del control del sistema immune\u201d, explica el Dr. Esteller.<\/p>\n

Els investigadors han anomenat EPIMMUNE la marca epigen\u00e8tica que presenten alguns tumors de pulm\u00f3 i que fa que aquests tumors responguin millor a la immunoter\u00e0pia que els que no tenen la marca.<\/p>\n

\u201cEstudiant aquestes i altres empremtes epigen\u00e8tiques, el que volem \u00e9s poder predir la resposta del tumor a diversos f\u00e0rmacs amb la finalitat d\u2019optimitzar la ter\u00e0pia en els pacients que ja no responen als tractaments est\u00e0ndards\u201d afirma Anna Mart\u00ednez, coprimera autora del treball.<\/p>\n

El patr\u00f3 epigen\u00e8tic EPIMMUNE permet predir la resposta del c\u00e0ncer de pulm\u00f3 davant del tractament amb l\u2019antic\u00f2s PD-1, que \u00e9s una de les immunoter\u00e0pies m\u00e9s utilitzades en el camp de l\u2019oncologia m\u00e8dica. \u201cCon\u00e8ixer el perfil epigen\u00e8tic dels pacients t\u00e9 un gran valor cl\u00ednic perqu\u00e8 ens permet seleccionar-los i fer prediccions sobre quina ter\u00e0pia ser\u00e0 m\u00e9s efectiva en cada persona\u201d, explica la investigadora Anna Mart\u00ednez.<\/p>\n

\u201cEl seg\u00fcent pas d\u2019aquest projecte \u00e9s el d\u2019ampliar l\u2019aplicabilitat de la firma EPIMMUNE a d\u2019altres tipus de c\u00e0ncer on la immunoter\u00e0pia ja t\u00e9 un paper crucial, com el melanoma; o a d\u2019altres c\u00e0ncers en els quals aquests tractaments semblen prometedors, com els tumors urotelials\u201d comenta l\u2019Anna Mart\u00ednez. \u201cPoder seleccionar aquells pacients que respondran al tractament \u00e9s clau per a l\u2019evoluci\u00f3 positiva del pacient\u201d.<\/p>\n

L\u2019estudi, que t\u00e9 el suport de l\u2019Obra Social \u201dla Caixa\u201d, s\u2019ha publicat a la prestigiosa revista The Lancet Respiratory Medicine i forma part d\u2019un assaig cl\u00ednic amb 100 pacients. La col\u00b7laboraci\u00f3 entre investigadors b\u00e0sics, aplicats i cl\u00ednics ha fet possible aquest aven\u00e7 en la cursa per millorar les ter\u00e0pies per al c\u00e0ncer de pulm\u00f3.<\/p>\n

Refer\u00e8ncies:<\/strong><\/span><\/p>\n

\u2022 <\/span>Epigenetic prediction of response to anti-PD-1 treatment in non-small-cell lung cancer: a multicentre, retrospective analysis.<\/a><\/span>
\u2022 <\/span>The Cancer Immunotherapy Revolution.<\/a><\/span><\/p>\n<\/p><\/div>\n

<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n

Post de l’Obra Social “la Caixa”<\/p>\n

Immunoter\u00e0pia. f. Med. Ter\u00e0pia basada en l\u2019\u00fas de subst\u00e0ncies per estimular o reprimir el sistema immune i ajudar el cos a combatre el c\u00e0ncer, infeccions i altres malalties.<\/p>\n

$\"\"$
Visi\u00f3 microsc\u00f2pica d\u2019un c\u00e0ncer de pulm\u00f3 on les c\u00e8l\u00b7lules immunes (marr\u00f3) s\u2019infiltren en les c\u00e8l\u00b7lules tumorals (blau).<\/p>\n