{"id":2097,"date":"2018-09-27T00:00:00","date_gmt":"2018-09-27T00:00:00","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=2097"},"modified":"2020-05-05T08:31:44","modified_gmt":"2020-05-05T08:31:44","slug":"quatre-linies-de-recerca-per-afrontar-les-malalties-del-cor","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/quatre-linies-de-recerca-per-afrontar-les-malalties-del-cor\/","title":{"rendered":"Quatre l\u00ednies de recerca per afrontar les malalties del cor"},"content":{"rendered":"

<\/p>\n

\n

Post de l\u2019Obra Social \u201dla Caixa\u201d<\/strong><\/p>\n

La malaltia cardiovascular (MCV) \u00e9s la primera causa de mortalitat arreu del m\u00f3n. Cada any 17,5 milions de persones moren per MCV i s\u2019estima que, el 2030, aquesta xifra arribi als 23,6 milions de defuncions anuals.<\/p>\n

La MCV compr\u00e8n un grup ampli de malalties, que inclouen des de les cardiopaties fins a les malalties cerebrovasculars. Afortunadament, es pot reduir el risc de patir-ne algunes adoptant certes mesures de prevenci\u00f3, com abandonar el consum de tabac, seguir una dieta sana i fer activitat f\u00edsica de manera regular.<\/p>\n

\"\"<\/p>\n

Un altre avantatge fonamental per lluitar contra la MCV \u00e9s la recerca. En aquest context, no \u00e9s estrany que a la primera Convocat\u00f2ria de Recerca en Salut<\/a> llan\u00e7ada enguany per l\u2019Obra Social \u201dla Caixa\u201d, 4 d\u2019un total de 20 projectes seleccionats s\u2019adrecin a millorar i desenvolupat nous m\u00e8todes diagn\u00f2stics i terap\u00e8utics per a la MCV. Des de CaixaCi\u00e8ncia ens volem afegir a la campanya del Dia Mundial del Cor submergint-nos en aquests 4 projectes pioners en el camp de la recerca cardiovascular.<\/p>\n

Anticossos per prevenir els accidents cardiovasculars<\/strong><\/p>\n

Liderat per la investigadora Almudena Ramiro, del Centre Nacional d\u2019Investigacions Cardiovasculars<\/a> (CNIC), el projecte busca nous m\u00e8todes de prevenci\u00f3 de l\u2019accident cardiovascular.<\/p>\n

Sovint, els accidents cardiovasculars es produeixen com a conseq\u00fc\u00e8ncia d\u2019un remodelatge vascular patol\u00f2gic, que \u00e9s un proc\u00e9s an\u00f2mal de canvis a les parets dels vasos sanguinis. Actualment se sap que la resposta immune contribueix en el remodelatge vascular patol\u00f2gic, per\u00f2 els biomarcadors descrits fins ara no s\u00f3n suficients per prevenir-la. Aquest projecte vol aprofundir en com la resposta immune mitjan\u00e7ada per anticossos participa en el remodelatge vascular patol\u00f2gic per poder identificar nous biomarcadors de prevenci\u00f3 d\u2019aquesta malaltia.<\/p>\n

\"\"
Anticossos de ratolins amb ateroesclerosi reconeixen la placa d’ateroma.<\/span><\/p>\n

A la recerca de nous factors de risc de l\u2019ateroesclerosi<\/strong><\/p>\n

Liderat per l\u2019investigador Valent\u00ed Fuster, del CNIC, el projecte espera identificar nous factors de risc que determinin quines persones presenten un risc cardiovascular alt quan l\u2019ateroesclerosi encara es troba en fases primerenques.<\/p>\n

A l\u2019ateroesclerosi t\u00e9 lloc un enduriment de les art\u00e8ries i una acumulaci\u00f3 de greix i colesterol que impedeix un bon reg sanguini. Tot i aquestes caracter\u00edstiques, durant els primers anys de la malaltia l\u2019ateroesclerosi pot no mostrar s\u00edmptomes en el pacient i, per aix\u00f2, \u00e9s de vital import\u00e0ncia identificar nous factors de risc capa\u00e7os de predir l\u2019evoluci\u00f3 de la malaltia en persones que encara no manifesten seq\u00fceles cl\u00edniques.<\/p>\n

\"\"
Descobrir els factors que afavoreixen el desenvolupament accelerat de l\u2019ateroesclerosi\u00e9s la finalitat d\u2019aquest estudi.<\/span><\/p>\n

Les dues cares de la inflamaci\u00f3: prevenir la lesi\u00f3 vascular sense comprometre les defenses<\/strong><\/p>\n

Liderat per l\u2019investigador Andr\u00e9s Hidalgo Alonso, del CNIC, el projecte explora una nova estrat\u00e8gia terap\u00e8utica que, mitjan\u00e7ant la regulaci\u00f3 del rellotge immunitari, pugui prevenir malalties cardiovasculars com l\u2019infart de miocardi i l\u2019ictus.<\/p>\n

La inflamaci\u00f3 \u00e9s una resposta natural del sistema immunitari per fer front a infeccions. No obstant aix\u00f2, les c\u00e8l\u00b7lules inflamat\u00f2ries que viatgen pel torrent circulatori \u2014com els neutr\u00f2fils\u2014 desenvolupen un paper clau en les lesions vasculars primerenques. Anul\u00b7lar l\u2019activitat dels neutr\u00f2fils no resultaria una bona estrat\u00e8gia terap\u00e8utica, ja que s\u00f3n imprescindibles per a les defenses de l\u2019organisme. Aquest projecte persegueix programar els neutr\u00f2fils per reduir les seves funcions perjudicials mantenint la seva capacitat de defensa immunit\u00e0ria.<\/p>\n

\"\"
L\u2019infart de miocardi i l\u2019ictus s\u00f3n els dos objectius de prevenci\u00f3 d\u2019aquest estudi.<\/span><\/p>\n

Els canvis metab\u00f2lics que permeten la formaci\u00f3 del cor prometen noves ter\u00e0pies regeneratives<\/strong><\/p>\n

Liderat per la investigadora Ofelia Mar\u00eda Mart\u00ednez Estrada, de la Fundaci\u00f3 Bosch i Gimpera<\/a> de la Universitat de Barcelona<\/a>, el projecte aprofundeix en el paral\u00b7lelisme que hi ha entre els mecanismes moleculars que regeixen la formaci\u00f3 del cor en l\u2019etapa embrion\u00e0ria i el proc\u00e9s de regeneraci\u00f3 del m\u00fascul card\u00edac despr\u00e9s d\u2019un infart.<\/p>\n

En un context de lesi\u00f3, l\u2019epicardi \u2014la capa externa del cor\u2014 pot actuar com a font de c\u00e8l\u00b7lules mare per a la regeneraci\u00f3 card\u00edaca, fet que el converteix en un teixit d\u2019especial inter\u00e8s en el camp de les ter\u00e0pies regeneratives del cor. Aquest projecte estudiar\u00e0 detalladament els canvis metab\u00f2lics de les c\u00e8l\u00b7lules de l\u2019epicardi durant el desenvolupament embrionari del cor per posar les bases de possibles futures estrat\u00e8gies de regeneraci\u00f3 card\u00edaca.<\/p>\n

\"\"
Imatge de microsc\u00f2pia de fluoresc\u00e8ncia d’una secci\u00f3 d’un cor embrionari del ratol\u00ed transg\u00e8nic WT1-Cre mT\/mG. A la imatge es poden observar les c\u00e8l\u00b7lules derivades de WT1 en verd, i la resta de c\u00e8l\u00b7lules del miocardi, en vermell.<\/span><\/p>\n

Refer\u00e8ncia<\/u>:<\/p>\n

\u2022 Organitzaci\u00f3 Mundial de la Salut: Malalties cardiovasculars<\/a>.<\/p>\n<\/p><\/div>\n

<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n

Post de l\u2019Obra Social \u201dla Caixa\u201d<\/p>\n

La malaltia cardiovascular (MCV) \u00e9s la primera causa de mortalitat arreu del m\u00f3n. Cada any 17,5 milions de persones moren per MCV i s\u2019estima que, el 2030, aquesta xifra arribi als 23,6 milions de defuncions anuals.<\/p>\n

La MCV compr\u00e8n un grup ampli de malalties, que inclouen des de les cardiopaties fins a les malalties cerebrovasculars. Afortunadament, es pot reduir el risc de patir-ne algunes adoptant certes mesures de prevenci\u00f3, com abandonar el consum de tabac, seguir una dieta sana i fer activitat f\u00edsica de manera regular.<\/p>\n

\"\"<\/p>\n

Un altre avantatge fonamental per lluitar contra la MCV \u00e9s la recerca. En aquest context,<\/p>\n","protected":false},"author":1,"featured_media":2703,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519],"tags":[436,437,185,438,386,387,439],"class_list":["post-2097","post","type-post","status-publish","format-standard","hentry","category-investigacio","tag-aterosclerosi","tag-factor-de-risc","tag-ictus","tag-immunologia","tag-infart-de-miocardi","tag-malaltia-cardiovascular","tag-regeneracio-cellular"],"acf":[],"yoast_head":"\nQuatre l\u00ednies de recerca per afrontar les malalties del cor - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/quatre-linies-de-recerca-per-afrontar-les-malalties-del-cor\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Quatre l\u00ednies de recerca per afrontar les malalties del cor - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Post de l\u2019Obra Social \u201dla Caixa\u201d La malaltia cardiovascular (MCV) \u00e9s la primera causa de mortalitat arreu del m\u00f3n. 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