{"id":2075,"date":"2018-11-14T00:00:00","date_gmt":"2018-11-14T00:00:00","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=2075"},"modified":"2020-05-13T10:59:44","modified_gmt":"2020-05-13T10:59:44","slug":"a-la-recerca-de-nous-tractaments-per-a-la-diabetis","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/a-la-recerca-de-nous-tractaments-per-a-la-diabetis\/","title":{"rendered":"A la recerca de nous tractaments per a la diabetis"},"content":{"rendered":"

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Post de l\u2019Obra Social \u201dla Caixa\u201d<\/strong><\/p>\n

Segons dades de l\u2019Organitzaci\u00f3 Mundial de la Salut<\/a> (OMS), en poc m\u00e9s de 30 anys, el nombre de persones amb diabetis s\u2019ha quadruplicat. El 2014 hi havia al m\u00f3n 422 milions de persones diagnosticades d\u2019aquesta malaltia metab\u00f2lica, que pot causar insufici\u00e8ncia renal i accidents cardiovasculars, entre d\u2019altres complicacions. L\u2019OMS preveu que la diabetis ser\u00e0 la setena causa de mortalitat al m\u00f3n el 2030.<\/p>\n

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\u201cLa diabetis afecta cada vegada m\u00e9s persones, i aix\u00f2 \u00e9s b\u00e0sicament perqu\u00e8 ha crescut molt la incid\u00e8ncia de la diabetis de tipus 2 (DM2), que, alhora, \u00e9s conseq\u00fc\u00e8ncia de l\u2019augment de l\u2019obesitat\u201d, assegura Manuel V\u00e1zquez Carrera, catedr\u00e0tic de Farmacologia, Toxicologia i Qu\u00edmica Terap\u00e8utica<\/a> de la Universitat de Barcelona<\/a> (UB). Normalment, la DM2 apareix en l\u2019edat adulta i en principi no requereix ter\u00e0pia amb insulina, per\u00f2 a mesura que la malaltia progressa, els tractaments amb f\u00e0rmacs orals deixen de ser efica\u00e7os i cal rec\u00f3rrer a injeccions subcut\u00e0nies d\u2019aquesta hormona. Per aix\u00f2, hi ha una necessitat important per desenvolupar nous f\u00e0rmacs orals.<\/p>\n

\u00a0\u201cEl nostre organisme sintetitza de manera natural una prote\u00efna anomenada FGF21, que t\u00e9 un potent efecte antidiab\u00e8tic. Diverses empreses estan desenvolupant an\u00e0legs \u2014una modificaci\u00f3 de la prote\u00efna original\u2014 per combatre la DM2, per\u00f2 no es poden administrar per via oral perqu\u00e8 es destruirien a l\u2019est\u00f3mac, aix\u00ed que s\u2019han de d\u2019administrar per via subcut\u00e0nia\u201d, explica l\u2019investigador de la UB.<\/p>\n

Amb l\u2019objectiu de trobar una soluci\u00f3 a aquesta problem\u00e0tica, V\u00e1zquez lidera el projecte HRI activators<\/a>, un dels 20 seleccionats en la convocat\u00f2ria d\u2019enguany<\/a> de CaixaImpulse<\/a>. Ell i el seu equip han descobert un nou f\u00e0rmac que, a trav\u00e9s de l\u2019activaci\u00f3 d\u2019un enzim anomenat HRI, provoca un augment dels nivells end\u00f2gens d\u2019FGF21. \u201cEn animals de laboratori ja hem demostrat que \u00e9s \u00fatil per reduir la hipergluc\u00e8mia causada per la malaltia i, a m\u00e9s, es pot administrar per via oral\u201d, assegura.<\/p>\n

D\u2019altra banda, segons V\u00e1zquez, \u201cels an\u00e0legs s\u2019han relacionat amb efectes adversos, com ara l\u2019augment de la freq\u00fc\u00e8ncia card\u00edaca i de la pressi\u00f3 arterial, i possiblement tamb\u00e9 osteoporosi\u201d. L\u2019especialista considera que l\u2019aproximaci\u00f3 terap\u00e8utica en qu\u00e8 treballen podria evitar aquests efectes secundaris. Per tot aix\u00f2, aquest nou f\u00e0rmac podria suposar una gran difer\u00e8ncia.<\/p>\n

\u201cGr\u00e0cies a CaixaImpulse, desenvoluparem aquest f\u00e0rmac, en farem una prova de concepte i en millorarem les caracter\u00edstiques farmacocin\u00e8tiques\u201d, afirma V\u00e1zquez. L\u2019objectiu final \u00e9s deixar el producte a punt per ser transferit a una companyia biotecnol\u00f2gica perqu\u00e8 pugui arribar al mercat i, per tant, als pacients.<\/p>\n<\/p><\/div>\n

<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n

Post de l\u2019Obra Social \u201dla Caixa\u201d<\/p>\n

Segons dades de l\u2019Organitzaci\u00f3 Mundial de la Salut<\/a> (OMS), en poc m\u00e9s de 30 anys, el nombre de persones amb diabetis s\u2019ha quadruplicat. El 2014 hi havia al m\u00f3n 422 milions de persones diagnosticades d\u2019aquesta malaltia metab\u00f2lica, que pot causar insufici\u00e8ncia renal i accidents cardiovasculars, entre d\u2019altres complicacions. L\u2019OMS preveu que la diabetis ser\u00e0 la setena causa de mortalitat al m\u00f3n el 2030.<\/p>\n

\"\"<\/p>\n

\u201cLa diabetis afecta cada vegada m\u00e9s persones, i aix\u00f2 \u00e9s b\u00e0sicament perqu\u00e8 ha crescut molt la incid\u00e8ncia de la diabetis de tipus 2 (DM2), que, alhora, \u00e9s conseq\u00fc\u00e8ncia de l\u2019augment de l\u2019obesitat\u201d, assegura Manuel V\u00e1zquez Carrera,<\/p>\n","protected":false},"author":1,"featured_media":2711,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519],"tags":[10,418,419,355,365],"class_list":["post-2075","post","type-post","status-publish","format-standard","hentry","category-investigacio","tag-caixaimpulse","tag-dia-mundial-de-la-diabetis","tag-farmacs","tag-innovacio","tag-recerca"],"acf":[],"yoast_head":"\nA la recerca de nous tractaments per a la diabetis - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/a-la-recerca-de-nous-tractaments-per-a-la-diabetis\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A la recerca de nous tractaments per a la diabetis - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Post de l\u2019Obra Social \u201dla Caixa\u201d Segons dades de l\u2019Organitzaci\u00f3 Mundial de la Salut (OMS), en poc m\u00e9s de 30 anys, el nombre de persones amb diabetis s\u2019ha quadruplicat. 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