{"id":2049,"date":"2019-02-01T00:00:00","date_gmt":"2019-02-01T00:00:00","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=2049"},"modified":"2020-04-30T09:07:32","modified_gmt":"2020-04-30T09:07:32","slug":"cancer-les-terapies-del-futur","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/cancer-les-terapies-del-futur\/","title":{"rendered":"C\u00e0ncer: les ter\u00e0pies del futur"},"content":{"rendered":"

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Sota el terme c\u00e0ncer<\/em> s\u2019agrupen m\u00e9s de 200 malalties diferents que s\u00f3n la segona causa de mort al m\u00f3n. Segons dades de l\u2019Associaci\u00f3 Espanyola Contra el C\u00e0ncer<\/a> (AECC), es calcula que el c\u00e0ncer afectar\u00e0 un de cada dos homes i una de cada tres dones al llarg de la seva vida. Davant d\u2019aquesta crua realitat, la recerca t\u00e9 un paper crucial a l\u2019hora de prevenir, curar o cronificar el c\u00e0ncer en el futur.<\/p>\n

La investigaci\u00f3 oncol\u00f2gica \u00e9s una de les l\u00ednies priorit\u00e0ries d\u2019actuaci\u00f3 de \u201dla Caixa\u201d. El 2018 s\u2019han destinat m\u00e9s de 8,6 milions d\u2019euros en ajuts a beques i a la recerca sobre el c\u00e0ncer. Aix\u00f2 ha perm\u00e8s finan\u00e7ar 85 projectes de recerca i contractar 50 investigadors.<\/p>\n

Amb motiu de la celebraci\u00f3 del Dia Mundial contra el C\u00e0ncer, parlem amb els responsables de tres projectes que obren la porta a tractaments innovadors i ter\u00e0pies personalitzades per tal de lluitar contra aquesta malaltia.<\/p>\n

<\/iframe><\/p>\n<p> <strong>Edici\u00f3 g\u00e8nica<\/strong><\/p>\n<p> La Sandra Rodr\u00edguez \u00e9s investigadora del <a href=\"https:\/\/www.cnio.es\/\" rel=\"noopener noreferrer\" target=\"_blank\">CNIO<\/a> i la responsable del projecte <a href=\"https:\/\/caixaimpulse.com\/es\/projects\/-\/caixaimpulse\/project\/FUGETHERAPEUTICS\" rel=\"noopener noreferrer\" target=\"_blank\">FuGe Therapeutics<\/a>, seleccionat en la convocat\u00f2ria <a href=\"https:\/\/caixaimpulse.com\/es\/home\" rel=\"noopener noreferrer\" target=\"_blank\">CaixaImpulse<\/a> 2018.<\/p>\n<p> Aquest projecte t\u00e9 l\u2019objectiu d\u2019aplicar t\u00e8cniques d\u2019edici\u00f3 g\u00e8nica sobre els gens de fusi\u00f3, un tipus de gen h\u00edbrid que sol estar implicat en alguns tipus de leuc\u00e8mia, c\u00e0ncer de colon i pr\u00f2stata. La tecnologia d\u2019edici\u00f3 g\u00e8nica CRISPR\/Cas9 permet manipular l\u2019ADN de la c\u00e8l\u00b7lula tumoral i eliminar els gens de fusi\u00f3 responsables de la proliferaci\u00f3 cel\u00b7lular descontrolada t\u00edpica del c\u00e0ncer. \u201cAmb aquesta eina tenim una efici\u00e8ncia molt superior a la que ten\u00edem amb eines anteriors: \u00e9s molt dirigida, molt precisa i molt barata\u201d.<\/p>\n<p> L\u2019aparici\u00f3 d\u2019aquesta nova tecnologia permetr\u00e0 desenvolupar noves ter\u00e0pies. En un futur, s\u2019espera aplicar-la a les anomenades <em>malalties \u00f2rfenes<\/em>, com ara el glioblastoma, que s\u00f3n molt agressives i que actualment no tenen tractament, o b\u00e9 a aquelles malalties per les quals ja tenim un tractament, per\u00f2 que s\u2019hi produeixen resist\u00e8ncies.<\/p>\n<p> <strong>Antiandr\u00f2gens de nova generaci\u00f3<\/strong><\/p>\n<p> L\u2019Eva Est\u00e9banez-Perpi\u00f1\u00e1 \u00e9s investigadora a la <a href=\"http:\/\/www.fbg.ub.edu\/\" rel=\"noopener noreferrer\" target=\"_blank\">Fundaci\u00f3 Bosch i Gimpera<\/a> de la Universitat de Barcelona. La seva recerca se centra en el paper que tenen els receptors d\u2019andr\u00f2gens en l\u2019aparici\u00f3 de resist\u00e8ncies durant el tractament del c\u00e0ncer de pr\u00f2stata, el segon m\u00e9s diagnosticat en homes.<\/p>\n<p> \u201cLa nostra recerca es basa en el receptor d\u2019andr\u00f2gens, perqu\u00e8 \u00e9s la prote\u00efna central en l\u2019inici, el manteniment i el desenvolupament del c\u00e0ncer de pr\u00f2stata\u201d.<\/p>\n<p> Els f\u00e0rmacs actuals per tractar el c\u00e0ncer de pr\u00f2stata perden l\u2019efic\u00e0cia als cinc anys. El projecte <a href=\"https:\/\/caixaimpulse.com\/ca\/projects\/-\/caixaimpulse\/project\/ARDIS\" rel=\"noopener noreferrer\" target=\"_blank\">ARDIs<\/a>, seleccionat tamb\u00e9 en la convocat\u00f2ria <a href=\"https:\/\/caixaimpulse.com\/es\/home\" rel=\"noopener noreferrer\" target=\"_blank\">CaixaImpulse<\/a> 2018, es proposa desenvolupar\u00a0f\u00e0rmacs contra el c\u00e0ncer de pr\u00f2stata amb un nou model d’acci\u00f3, capa\u00e7 d’evitar la resist\u00e8ncia als antiandr\u00f2gens cl\u00e0ssics.\u00a0<\/p>\n<p> <strong>Immunoter\u00e0pia<\/strong><\/p>\n<p> Per \u00faltim, l\u2019\u00c1lvaro Teijeira \u00e9s becari postdoctoral de “la Caixa” al <a href=\"https:\/\/cima.unav.edu\/\" rel=\"noopener noreferrer\" target=\"_blank\">Centro de Investigaci\u00f3n M\u00e9dica Aplicada de la Universidad de Navarra (CIMA-UNAV)<\/a>, on fa recerca en immunoter\u00e0pia. Concretament, estudia les interaccions entre les c\u00e8l\u00b7lules del sistema immunitari i les c\u00e8l\u00b7lules tumorals.<\/p>\n<p> La seva recerca analitza, mitjan\u00e7ant l\u2019observaci\u00f3 directa amb t\u00e8cniques de microsc\u00f2pia, com es comporten les c\u00e8l\u00b7lules del sistema immunitari davant les c\u00e8l\u00b7lules tumorals, quins s\u00f3n els mecanismes pels quals aquestes \u00faltimes impedeixen l\u2019acci\u00f3 del sistema immunitari i com actuen davant l\u2019exposici\u00f3 a diferents f\u00e0rmacs. \u201cCal que els tumors que les c\u00e8l\u00b7lules del sistema immunitari no reconeixen siguin reconeguts com a agents pat\u00f2gens\u201d.<\/p>\n<p> La immunoter\u00e0pia est\u00e0 canviant el tractament del c\u00e0ncer, per\u00f2 encara no \u00e9s eficient per a tots els pacients i, per tant, el gran repte de futur ser\u00e0 obtenir biomarcadors per desenvolupar una medicina personalitzada.<\/p>\n<\/p><\/div>\n<p><\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n<p> Sota el terme <em>c\u00e0ncer<\/em> s\u2019agrupen m\u00e9s de 200 malalties diferents que s\u00f3n la segona causa de mort al m\u00f3n. Segons dades de l\u2019<a href=\"https:\/\/www.aecc.es\/es\" rel=\"noopener noreferrer\" target=\"_blank\">Associaci\u00f3 Espanyola Contra el C\u00e0ncer<\/a> (AECC), es calcula que el c\u00e0ncer afectar\u00e0 un de cada dos homes i una de cada tres dones al llarg de la seva vida. Davant d\u2019aquesta crua realitat, la recerca t\u00e9 un paper crucial a l\u2019hora de prevenir, curar o cronificar el c\u00e0ncer en el futur.<\/p>\n<p> La investigaci\u00f3 oncol\u00f2gica \u00e9s una de les l\u00ednies priorit\u00e0ries d\u2019actuaci\u00f3 de \u201dla Caixa\u201d. El 2018 s\u2019han destinat m\u00e9s de 8,6 milions d\u2019euros en ajuts a beques i a la recerca sobre el c\u00e0ncer. Aix\u00f2 ha perm\u00e8s finan\u00e7ar 85 projectes de recerca i contractar 50 investigadors.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519],"tags":[36,124,123,37,349,397,125],"class_list":["post-2049","post","type-post","status-publish","format-standard","hentry","category-investigacio","tag-cancer","tag-cancer-de-prostata","tag-crispr","tag-dia-mundial-contra-el-cancer","tag-edicio-genica","tag-immunoterapia","tag-terapia"],"acf":[],"yoast_head":"\n<title>C\u00e0ncer: les ter\u00e0pies del futur - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/cancer-les-terapies-del-futur\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"C\u00e0ncer: les ter\u00e0pies del futur - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Sota el terme c\u00e0ncer s\u2019agrupen m\u00e9s de 200 malalties diferents que s\u00f3n la segona causa de mort al m\u00f3n. Segons dades de l\u2019Associaci\u00f3 Espanyola Contra el C\u00e0ncer (AECC), es calcula que el c\u00e0ncer afectar\u00e0 un de cada dos homes i una de cada tres dones al llarg de la seva vida. Davant d\u2019aquesta crua realitat, la recerca t\u00e9 un paper crucial a l\u2019hora de prevenir, curar o cronificar el c\u00e0ncer en el futur. La investigaci\u00f3 oncol\u00f2gica \u00e9s una de les l\u00ednies priorit\u00e0ries d\u2019actuaci\u00f3 de \u201dla Caixa\u201d. El 2018 s\u2019han destinat m\u00e9s de 8,6 milions d\u2019euros en ajuts a beques i a la recerca sobre el c\u00e0ncer. 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