<\/iframe><\/p>\n El cos hum\u00e0 \u00e9s la llar d\u2019uns cent bilions de microorganismes, entre els quals hi ha bacteris, fongs, virus i altres microbis. Tots s\u2019allotgen en teixits que estan en contacte amb l\u2019ambient extern, amb les mucoses, la pell o al tracte digestiu, i formen la microbiota. L\u2019estudi de la microbiota i els seus gens \u00e9s el que es coneix com el microbioma i, fa ben poc, hem comen\u00e7at a dilucidar-ne el paper en el desenvolupament de diversos tipus de c\u00e0ncer. Entendre millor el microbioma \u00e9s ara una necessitat en la recerca oncol\u00f2gica.<\/p>\n Amb motiu del Dia Mundial del Microbioma, entrevistem Josep Tabernero, director del <a href=\"http:\/\/www.vhio.net\/es\/\" rel=\"noopener noreferrer\" target=\"_blank\">Vall d\u2019Hebron Institut d\u2019Oncologia<\/a> (VHIO) i l\u00edder de la <a href=\"http:\/\/www.vhio.net\/es\/research-unit-for-molecular-therapy-of-cancer-la-caixa\/\" rel=\"noopener noreferrer\" target=\"_blank\">Unitat de Recerca de Ter\u00e0pia Molecular del C\u00e0ncer – \u201dla Caixa\u201d<\/a> del VHIO. L\u2019investigador ens explica la relaci\u00f3 entre el microbioma i el c\u00e0ncer colorectal i ens parla del projecte <a href=\"http:\/\/www.vhio.net\/es\/optimisticc-vhio-awarded-grand-challenge-funding-from-cruk-to-tackle-cancers-biggest-questions\/\" rel=\"noopener noreferrer\" target=\"_blank\">OPTIMISTICC<\/a> (Opportunity To Investigate the Microbiome\u2019s Impact on Science and Treatment In Colorectal Cancer<\/em>). OPTIMISTICC \u00e9s un dels projectes guanyadors del <a href=\"https:\/\/www.cancerresearchuk.org\/funding-for-researchers\/how-we-deliver-research\/grand-challenge-award\" rel=\"noopener noreferrer\" target=\"_blank\">Grand Challenge<\/a> del Cancer Research UK, un programa de finan\u00e7ament competitiu d\u2019\u00e0mbit internacional per donar resposta a les grans preguntes en la recerca del c\u00e0ncer.<\/p>\n Per qu\u00e8 \u00e9s tan important el microbioma?<\/strong><\/p>\n Si tenim en compte el nombre de gens al nostre organisme, nom\u00e9s el 0,01 % s\u00f3n gens humans. La resta s\u00f3n gens de microorganismes que viuen al nostre interior. Aix\u00f2 ens dona una idea de la dimensi\u00f3 que tot aquest component extrahum\u00e0 pot tenir en m\u00faltiples processos que es duen a terme cont\u00ednuament en el cos hum\u00e0.<\/p>\n Com afecta la nostra salut?<\/strong><\/p>\n El microbioma s\u2019ha d\u2019entendre com un gran reactor dins de l\u2019organisme que produeix cont\u00ednuament metab\u00f2lits i prote\u00efnes que ens ajuden en moltes funcions com ara promoure el sistema immunitari.<\/p>\n Hi ha cap vincle entre el c\u00e0ncer i el microbioma?<\/strong><\/p>\n La relaci\u00f3 entre el microbioma i el c\u00e0ncer \u00e9s molt important i cada vegada es coneix millor. El microbioma ha estat sempre dins nostre, per\u00f2 no li hav\u00edem donat gaire import\u00e0ncia, excepte quan ten\u00edem diarrees, disbacteriosis o altres malalties del tracte digestiu. No obstant aix\u00f2, avui dia sabem que, en el c\u00e0ncer colorectal, des d\u2019un moment molt inicial, parteix del genoma d\u2019alguns bacteris, s\u2019integra a les c\u00e8l\u00b7lules de la mucosa del c\u00f2lon i fa que el tumor es desenvolupi i progressi.<\/p>\n <img decoding=\"async\" alt=\"Pathogenic E. coli on the intestinal lining - S. Schuller\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2020\/04\/ca\/Pathogenic+E.+coli+on+the+intestinal+lining+-+S.+Schuller.jpg\" style=\"width: 400px; height: 400px;\"\/> E. coli pat\u00f2gena en el revestiment intestinal – S. Schuller<\/p>\n Aquest descobriment \u00e9s del seu equip.<\/strong><\/p>\n De fet, ho vam descobrir una mica per casualitat l\u2019any 2012 amb un grup de recerca de Boston. Vam trobar fragments d\u2019un bacteri del g\u00e8nere Fusobacterium<\/em> al genoma del tumor. Al principi vam pensar que era un error, un artefacte, per\u00f2 despr\u00e9s vam veure amb diverses mostres que no era aix\u00ed. Des d\u2019aleshores, hem pogut comprovar que el genoma dels bacteris no nom\u00e9s es pot trobar a les c\u00e8l\u00b7lules del tumor primari, sin\u00f3 que tamb\u00e9 a les de met\u00e0stasi.<\/p>\n Quines aplicacions pot tenir aquest descobriment?<\/strong><\/p>\n En estudis de laboratori amb ratolins hem vist que, si apliquem un tractament amb antibi\u00f2tics, potenciem l\u2019efecte d\u2019algunes ter\u00e0pies contra el c\u00e0ncer de c\u00f2lon.<\/p>\n Aquest \u00e9s el nucli del projecte OPTIMISTICC, del qual forma part com un dels investigadors principals.<\/strong><\/p>\n Amb aquest projecte, que duem a terme en col\u00b7laboraci\u00f3 amb diverses entitats europees i americanes, volem entendre millor el paper del microbioma en tots els aspectes del c\u00e0ncer colorectal. No nom\u00e9s en el tractament quan ja tenim la malaltia o quan s\u2019ha desenvolupat la met\u00e0stasi, sin\u00f3 en com podr\u00edem ajudar tamb\u00e9 a prevenir-lo.<\/p>\n De qu\u00e8 dep\u00e8n que el meu microbioma es desenvolupi correctament?<\/strong><\/p>\n De m\u00faltiples factors. Ara s\u2019est\u00e0 comen\u00e7ant a estudiar quin impacte t\u00e9 la lact\u00e0ncia materna en el desenvolupament del microbioma durant la inf\u00e0ncia. I el que ja s\u2019ha descobert \u00e9s que la prolongaci\u00f3 de la lact\u00e0ncia durant m\u00e9s de 6 mesos \u2013probablement fins a un any\u2013 ajuda a mantenir el microbioma adequat a les fases inicials del desenvolupament del nen. A m\u00e9s, aquesta prolongaci\u00f3 no requereix una lact\u00e0ncia completa, sin\u00f3 que amb preses individuals di\u00e0ries n\u2019hi hauria prou.<\/p>\n La lact\u00e0ncia materna pot condicionar l\u2019aparici\u00f3 de c\u00e0ncer?<\/strong><\/p>\n S\u00ed. De fet, alguns experts suggereixen que podr\u00edem reduir un 10 % els tumors que te\u00f2ricament es poden prevenir allargant la lact\u00e0ncia materna. Sembla que el moment inicial del desenvolupament dels infants \u00e9s clau perqu\u00e8 el microbioma es comenci a transformar des d\u2019un microbioma adequat, el que tots haur\u00edem de tenir, en un microbioma perjudicial, que fomenti l\u2019aparici\u00f3 de tumors.<\/p>\n<\/p><\/div>\n<\/body><\/html><\/p>\n","protected":false},"excerpt":{"rendered":"<\/p>\n <iframe loading=\"lazy\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen=\"\" frameborder=\"0\" height=\"225\" src=\"https:\/\/www.youtube.com\/embed\/bfVW8pmWwak\" width=\"400\"><\/iframe><\/p>\n El cos hum\u00e0 \u00e9s la llar d\u2019uns cent bilions de microorganismes, entre els quals hi ha bacteris, fongs, virus i altres microbis. Tots s\u2019allotgen en teixits que estan en contacte amb l\u2019ambient extern, amb les mucoses, la pell o al tracte digestiu, i formen la microbiota. L\u2019estudi de la microbiota i els seus gens \u00e9s el que es coneix com el microbioma i, fa ben poc, hem comen\u00e7at a dilucidar-ne el paper en el desenvolupament de diversos tipus de c\u00e0ncer. Entendre millor el microbioma \u00e9s ara una necessitat en la recerca oncol\u00f2gica.<\/p>\n Amb motiu del Dia Mundial del Microbioma, entrevistem Josep Tabernero, director del <a href=\"http:\/\/www.vhio.net\/es\/\" rel=\"noopener noreferrer\" target=\"_blank\">Vall d\u2019Hebron Institut d\u2019Oncologia<\/a> (VHIO) i l\u00edder de la <a href=\"http:\/\/www.vhio.net\/es\/research-unit-for-molecular-therapy-of-cancer-la-caixa\/\" rel=\"noopener noreferrer\" target=\"_blank\">Unitat de Recerca de Ter\u00e0pia Molecular del C\u00e0ncer –<\/a><\/p>\n","protected":false},"author":1,"featured_media":3024,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[519],"tags":[36,393,15,365,394],"class_list":["post-2007","post","type-post","status-publish","format-standard","hentry","category-investigacio","tag-cancer","tag-cancer-colorectal","tag-microbioma","tag-recerca","tag-recerca-oncologica"],"acf":[],"yoast_head":"\n<title>El microbioma, un poder\u00f3s aliat contra el c\u00e0ncer colorectal - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/el-microbioma-un-poderos-aliat-contra-el-cancer-colorectal\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El microbioma, un poder\u00f3s aliat contra el c\u00e0ncer colorectal - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"El cos hum\u00e0 \u00e9s la llar d\u2019uns cent bilions de microorganismes, entre els quals hi ha bacteris, fongs, virus i altres microbis. Tots s\u2019allotgen en teixits que estan en contacte amb l\u2019ambient extern, amb les mucoses, la pell o al tracte digestiu, i formen la microbiota. L\u2019estudi de la microbiota i els seus gens \u00e9s el que es coneix com el microbioma i, fa ben poc, hem comen\u00e7at a dilucidar-ne el paper en el desenvolupament de diversos tipus de c\u00e0ncer. Entendre millor el microbioma \u00e9s ara una necessitat en la recerca oncol\u00f2gica. Amb motiu del Dia Mundial del Microbioma, entrevistem Josep Tabernero, director del Vall d\u2019Hebron Institut d\u2019Oncologia (VHIO) i l\u00edder de la Unitat de Recerca de Ter\u00e0pia Molecular del C\u00e0ncer –\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blog.caixaresearch.org\/ca\/el-microbioma-un-poderos-aliat-contra-el-cancer-colorectal\/\" \/>\n<meta property=\"og:site_name\" content=\"Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"article:published_time\" content=\"2019-06-27T00:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-05-05T08:31:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2020\/04\/ca\/Pathogenic+E.+coli+on+the+intestinal+lining+-+S.+Schuller.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"760\" \/>\n\t<meta property=\"og:image:height\" content=\"760\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"La Caixa\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"La Caixa\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/blog.caixaresearch.org\/ca\/el-microbioma-un-poderos-aliat-contra-el-cancer-colorectal\/\",\"url\":\"https:\/\/blog.caixaresearch.org\/ca\/el-microbioma-un-poderos-aliat-contra-el-cancer-colorectal\/\",\"name\":\"El microbioma, un poder\u00f3s aliat contra el c\u00e0ncer colorectal - 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