{"id":10564,"date":"2025-06-21T09:00:18","date_gmt":"2025-06-21T08:00:18","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=10564"},"modified":"2025-06-20T11:53:29","modified_gmt":"2025-06-20T10:53:29","slug":"jo-tambe-investigo-per-curar-lela","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/jo-tambe-investigo-per-curar-lela\/","title":{"rendered":"\u00abJo tamb\u00e9 investigo per curar l\u2019ELA\u00bb"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10591\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Alguna cosa est\u00e0 canviant en la lluita contra l\u2019esclerosi lateral amiotr\u00f2fica (ELA).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Durant anys, aquesta malaltia neurodegenerativa ha estat sin\u00f2nim d\u2019<\/span><b>incertesa, patiment i manca d\u2019opcions terap\u00e8utiques<\/b><span style=\"font-weight: 400;\">. Per\u00f2 en aquests \u00faltims temps, els aven\u00e7os cient\u00edfics estan dibuixant un nou horitz\u00f3: per primera vegada, <\/span><a href=\"https:\/\/www.labiotech.eu\/best-biotech\/als-companies\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">emergeixen ter\u00e0pies innovadores, <\/span><i><span style=\"font-weight: 400;\">start-ups<\/span><\/i><span style=\"font-weight: 400;\"> especialitzades<\/span><\/a><span style=\"font-weight: 400;\"> i iniciatives que ofereixen resultats esperan\u00e7adors que podrien realment transformar el futur de l\u2019ELA.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aquest impuls col\u00b7lectiu no neix tan sols de grans empreses o laboratoris, sin\u00f3 que tamb\u00e9 pren forma en universitats, hospitals i centres de recerca d\u2019arreu del m\u00f3n, on investigadors, metges i experts treballen dia rere dia amb un objectiu compartit: comprendre l\u2019ELA i acostar-se al seu tractament.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">El Dia Mundial de l\u2019Esclerosi Lateral Amiotr\u00f2fica donem veu a algunes de les persones que, a la comunitat CaixaResearch, investiguen per fer possible aquest canvi i s\u2019uneixen en un missatge compartit: \u00ab<\/span><b>Jo tamb\u00e9 investigo per curar l\u2019ELA<\/b><span style=\"font-weight: 400;\">\u00bb.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<h3><b><i>Entendre i diagnosticar l\u2019ELA<\/i><\/b><\/h3>\n<p><span style=\"font-weight: 400;\">L\u2019esclerosi lateral amiotr\u00f2fica \u00e9s una malaltia neurodegenerativa progressiva i letal. Afecta les neurones encarregades de l\u2019activitat muscular volunt\u00e0ria, imprescindibles en funcions com caminar o parlar, per la qual cosa <\/span><b>acaba provocant la immobilitat <\/b><span style=\"font-weight: 400;\">i, finalment, la mort de la persona. Es calcula que afecta 2 de cada 100.000 persones a tot el m\u00f3n. A Espanya, tot i que no n\u2019hi ha cap registre oficial, entre 4.000 i 4.500 persones pateixen ELA, i cada any 700 persones desenvolupen els primers s\u00edmptomes de la malaltia, segons la <\/span><a href=\"https:\/\/www.sen.es\/saladeprensa\/pdf\/Link378.pdf\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Sociedad Espa\u00f1ola de Neurolog\u00eda<\/span><\/a><span style=\"font-weight: 400;\"> (SEN). Per a totes aquestes persones, l\u2019esperan\u00e7a de vida mitjana despr\u00e9s del diagn\u00f2stic \u00e9s de cinc anys, cosa que suposa tamb\u00e9<\/span><b> un cop psicol\u00f2gic molt dur<\/b><span style=\"font-weight: 400;\"> per al pacient i el seu cercle proper.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00abUn anunci de diagn\u00f2stic d\u2019ELA \u00e9s un daltabaix vital dif\u00edcil de descriure. \u00c9s una cat\u00e0strofe. \u00c9s l\u2019espasa de D\u00e0mocles que tens al damunt. \u00c9s una mort anunciada. I <\/span><b>\u00e9s dif\u00edcil<\/b><span style=\"font-weight: 400;\">, primer per al malalt i despr\u00e9s per als m\u00e9s propers, <\/span><b>digerir amb un m\u00ednim de racionalitat el que est\u00e0 passant<\/b><span style=\"font-weight: 400;\"> perqu\u00e8 d\u2019entrada sembla que no \u00e9s real, i d\u2019aqu\u00ed ve la frustraci\u00f3\u00bb, explica a <\/span><a href=\"https:\/\/mediahub.fundacionlacaixa.org\/ca\/investigacio-salut\/salut\/malalties\/2024-06-11\/ela-investigar-malaltia-encara-cura-afecta-4-000-pacients-5980.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">MediaHub<\/span><\/a><span style=\"font-weight: 400;\"> Mar\u00eda Jos\u00e9 Arregui, presidenta de la <\/span><a href=\"https:\/\/www.ffluzon.org\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Fundaci\u00f3n Luz\u00f3n<\/span><\/a><span style=\"font-weight: 400;\">, entitat amb la qual col\u00b7labora la Fundaci\u00f3 \u201dla\u00a0Caixa\u201d i que treballa per visibilitzar aquesta malaltia,\u00a0 millorar la qualitat de vida dels pacients i les seves fam\u00edlies, i promoure la recerca.\u00a0<\/span><\/p>\n<div id=\"attachment_10576\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10576\" class=\"wp-image-10576\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/MJose-Arregui-presidenta-Fundacion-Luzon_Blog-300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/MJose-Arregui-presidenta-Fundacion-Luzon_Blog-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/MJose-Arregui-presidenta-Fundacion-Luzon_Blog-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/MJose-Arregui-presidenta-Fundacion-Luzon_Blog-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/MJose-Arregui-presidenta-Fundacion-Luzon_Blog-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/MJose-Arregui-presidenta-Fundacion-Luzon_Blog-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-10576\" class=\"wp-caption-text\"><em>Mar\u00eda Jos\u00e9 Arregui, presidenta de la Fundaci\u00f3n Luz\u00f3n<\/em><\/p><\/div>\n<p><span style=\"font-weight: 400;\">Ho sap molt b\u00e9 <\/span><a href=\"https:\/\/becarios.fundacionlacaixa.org\/ca\/anabel-saez-mas-B005916?doAsUserId=GtlXOSwuzax6Pws4YFcy9w==\" target=\"_blank\" rel=\"noopener\"><b>Anabel S\u00e1ez Mas<\/b><\/a><span style=\"font-weight: 400;\">, bec\u00e0ria de la Fundaci\u00f3 \u201dla Caixa\u201d i doctoranda en el grup de l\u2019investigador CaixaResearch <\/span><a href=\"https:\/\/caixaresearch.org\/ca\/convocatoria-caixaresearch-investigacio-salut-2022-projecte-estres-esclerosi\" target=\"_blank\" rel=\"noopener\"><b>\u00d3scar Fern\u00e1ndez-Capetillo<\/b><\/a><span style=\"font-weight: 400;\"> al Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO). \u00abInvestigar l\u2019ELA \u00e9s per a mi un repte personal i cient\u00edfic. <\/span><b>El meu pare el van diagnosticar mentre jo estudiava la carrera<\/b><span style=\"font-weight: 400;\"> i des d\u2019aleshores he volgut contribuir a entendre millor aquesta malaltia\u00bb, explica S\u00e1ez Mas. \u00abL\u2019ELA \u00e9s un puzle amb moltes peces. Sovint no sabem qu\u00e8 \u00e9s el que la causa i hi ha moltes mutacions diferents implicades. Aix\u00f2 la converteix en un repte enorme que necessita respostes urgents\u00bb.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Per aquest motiu participa en el grup que dirigeix Fern\u00e1ndez-Capetillo, que treballa amb l\u2019objectiu d\u2019entendre les causes moleculars que inicien la mort de les neurones motrius en els pacients d\u2019ELA. \u00abEntendre el problema \u00e9s el primer pas per intentar trobar-hi solucions. Els nostres descobriments inicials apunten que les mutacions associades a l\u2019ELA deriven en l\u2019acumulaci\u00f3 de prote\u00efnes ribos\u00f2miques defectuoses, <\/span><b>una mena d\u2019\u201cescombraries moleculars\u201d que causa toxicitat<\/b><span style=\"font-weight: 400;\">. \u00c9s un fenomen que tamb\u00e9 s\u2019observa durant l\u2019envelliment\u00bb, indica l\u2019investigador CaixaResearch. \u00ab&#8221;En aquest context, estem intentant descobrir maneres d\u2019eliminar aquests agregats de prote\u00efnes ribos\u00f2miques, per poder explorar la seva possible utilitat com a nova aproximaci\u00f3 terap\u00e8utica per a l\u2019ELA.&#8221;\u00bb<\/span><\/p>\n<div id=\"attachment_10518\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10518\" class=\"wp-image-10518\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-2-300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-2-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-2-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-2-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-2-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-2-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-10518\" class=\"wp-caption-text\"><em>Anabel S\u00e1ez i Fern\u00e1ndez-Capetillo<\/em><\/p><\/div>\n<p><span style=\"font-weight: 400;\">Igual que Fern\u00e1ndez-Capetillo i S\u00e1ez Mas, la investigadora CaixaResearch <\/span><a href=\"https:\/\/caixaresearch.org\/es\/convocatoria-caixaresearch-investigacion-salud-2024-proyecto-tratamiento-ela\" target=\"_blank\" rel=\"noopener\"><b>Benedetta Bolognesi<\/b><\/a><span style=\"font-weight: 400;\">, de l\u2019Institut de Bioenginyeria de Catalunya (IBEC), treballa per entendre algunes de les causes de la malaltia. \u00abNosaltres ens centrem en la prote\u00efna SOD1, en la qual s\u2019han trobat m\u00e9s de 180 mutacions associades a la malaltia\u00bb, explica. La seva recerca forma part d\u2019un projecte a gran escala amb la Universitat de Wollongong i el Royal Melbourne Hospital, a Austr\u00e0lia, per <\/span><b>mapar l\u2019impacte de tots els canvis gen\u00e8tics <\/b><span style=\"font-weight: 400;\">de SOD1 en diferents mecanismes de la malaltia. \u00abAix\u00f2 permetr\u00e0 <\/span><b>un diagn\u00f2stic m\u00e9s preco\u00e7 i prec\u00eds<\/b><span style=\"font-weight: 400;\">, i tamb\u00e9 assentar\u00e0 les bases per a intervencions terap\u00e8utiques m\u00e9s espec\u00edfiques i eficaces per a tots els pacients amb ELA\u00bb.\u00a0<\/span><\/p>\n<div id=\"attachment_10530\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10530\" class=\"wp-image-10530\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog10-300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog10-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog10-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog10-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog10-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog10-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-10530\" class=\"wp-caption-text\"><em>Benedetta Bolognesi<\/em><\/p><\/div>\n<p><span style=\"font-weight: 400;\">La cerca de biomarcadors, mol\u00e8cules biol\u00f2giques que s\u00f3n al nostre organisme i que poden indicar la pres\u00e8ncia de la malaltia, \u00e9s un dels camps d\u2019acci\u00f3 m\u00e9s importants contra l\u2019ELA. Trobar-los pot suposar el<\/span><b> desenvolupament de proves diagn\u00f2stiques m\u00e9s r\u00e0pides i poc invasives<\/b><span style=\"font-weight: 400;\"> que podrien millorar el pron\u00f2stic de la malaltia. \u00abCrec que hi ha hagut un abans i un despr\u00e9s en la investigaci\u00f3 de l\u2019ELA. Hem aconseguit situar la malaltia a l\u2019agenda p\u00fablica i social, i fer-la atractiva per als investigadors\u00bb, assegura Mar\u00eda Jos\u00e9 Arregui, presidenta de la Fundaci\u00f3n Luz\u00f3n.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Un dels projectes que van en aquesta l\u00ednia s\u2019emmarca en la col\u00b7laboraci\u00f3 entre la Fundaci\u00f3 \u201dla Caixa\u201d i la Fundaci\u00f3n Luz\u00f3n. \u00c9s el projecte de <\/span><a href=\"https:\/\/caixaresearch.org\/ca\/convocatoria-caixaresearch-investigacio-salut-2020-projecte-ela\" target=\"_blank\" rel=\"noopener\"><b>Maite Mendioroz<\/b><\/a><span style=\"font-weight: 400;\"> i Ivonne Jeric\u00f3, investigadora de la Fundaci\u00f3n Miguel Servet (Navarrabiomed). El seu equip treballa en<\/span> <span style=\"font-weight: 400;\">una<\/span><b> t\u00e8cnica de diagn\u00f2stic desenvolupada en el camp de l\u2019oncologia per aplicar-la en pacients amb ELA<\/b><span style=\"font-weight: 400;\">: la bi\u00f2psia l\u00edquida. \u00abQuan les c\u00e8l\u00b7lules degeneren i moren alliberen el seu contingut, incl\u00f2s l\u2019ADN, al torrent sanguini. Aquestes mol\u00e8cules d\u2019ADN circulants contenen informaci\u00f3 bioqu\u00edmica sobre les seves c\u00e8l\u00b7lules d\u2019origen, que en el cas de l\u2019ELA s\u00f3n les neurones malaltes\u00bb, explica Mendioroz. \u00abEl que estem fent \u00e9s a\u00efllar i estudiar aquest ADN mitjan\u00e7ant una an\u00e0lisi de sang com una nova font de biomarcadors per desenvolupar una prova no invasiva que ajudi en el diagn\u00f2stic d\u2019aquestes malalties neurodegeneratives.\u00bb<\/span><\/p>\n<div id=\"attachment_10522\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10522\" class=\"wp-image-10522\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-13-300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-13-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-13-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-13-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-13-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-13-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-10522\" class=\"wp-caption-text\"><em>Maite Mendioroz i Ivonne Jeric\u00f3<\/em><\/p><\/div>\n<p><span style=\"font-weight: 400;\">Amb aquest objectiu treballa tamb\u00e9 l\u2019equip d\u2019<\/span><a href=\"https:\/\/caixaresearch.org\/ca\/convocatoria-caixaresearch-investigacio-salut-2023-projecte-esclerosi-amiotrofica\" target=\"_blank\" rel=\"noopener\"><b>Estela Area<\/b><\/a><span style=\"font-weight: 400;\">, investigadora CaixaResearch del Centro de Investigaciones Biol\u00f3gicas (CIB-CISC) Margarita Salas, tot i que amb un enfocament diferent. \u00abL\u2019ELA presenta m\u00faltiples disfuncions cel\u00b7lulars sense cap causa clara. El nostre treball proposa que <\/span><b>aquestes alteracions podrien tenir un origen com\u00fa<\/b><span style=\"font-weight: 400;\">: un defecte en la regulaci\u00f3 del metabolisme lip\u00eddic que afecta la funci\u00f3 de les membranes cel\u00b7lulars\u00bb, assenyala. \u00abEl nostre objectiu \u00e9s fer una an\u00e0lisi longitudinal dels canvis en el perfil lip\u00eddic de pacients amb ELA per trobar<\/span><b> biomarcadors<\/b><span style=\"font-weight: 400;\"> representatius de la malaltia que, en un futur, es puguin convertir en noves dianes terap\u00e8utiques per al seu tractament\u00bb.\u00a0<\/span><\/p>\n<div id=\"attachment_10514\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10514\" class=\"wp-image-10514\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog--300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog--300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog--1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog--768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog--1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog--2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-10514\" class=\"wp-caption-text\"><em>Estela Area<\/em><\/p><\/div>\n<p>&nbsp;<\/p>\n<h3><b><i>Per tractar i curar l\u2019ELA<\/i><\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Dins de la xarxa CaixaResearch tamb\u00e9 es treballa per trobar possibles tractaments per a la malaltia. L\u2019equip dirigit per <\/span><a href=\"https:\/\/caixaresearch.org\/ca\/convocatoria-caixaresearch-investigacio-salut-2021-projecte-terapies-ela\" target=\"_blank\" rel=\"noopener\"><b>Ana Mart\u00ednez<\/b><\/a><span style=\"font-weight: 400;\"> al Centro de Investigaciones Biol\u00f3gicas (CIB-CSIC) Margarita Salas se centra a<\/span><b> descobrir i desenvolupar candidats a f\u00e0rmacs<\/b><span style=\"font-weight: 400;\"> amb mecanismes d\u2019acci\u00f3 innovadors. \u00abTreballem per modular la TDP-43, una prote\u00efna del nucli de la c\u00e8l\u00b7lula que t\u00e9 multitud de funcions en la formaci\u00f3 d\u2019altres prote\u00efnes. Quan es produeix la malaltia, TDP-43 abandona el nucli i es localitza en el citoplasma, on forma agregats t\u00f2xics\u00bb, detalla Mart\u00ednez. \u00abNosaltres hem dissenyat diverses fam\u00edlies de compostos que disminueixen aquesta toxicitat i retornen TDP-43 al nucli\u00bb.\u00a0<\/span><\/p>\n<div id=\"attachment_10526\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10526\" class=\"wp-image-10526\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-10526\" class=\"wp-caption-text\"><em>Ana Mart\u00ednez<\/em><\/p><\/div>\n<p><span style=\"font-weight: 400;\">D\u2019altra banda, el grup de <\/span><a href=\"https:\/\/caixaresearch.org\/ca\/convocatoria-caixaimpulse-innovacio-salut-2024-biomarcadors-ela\" target=\"_blank\" rel=\"noopener\"><b>Manuel Portero<\/b><\/a><span style=\"font-weight: 400;\">, investigador de l\u2019Institut de Recerca Biom\u00e8dica de Lleida (IRBLleida) i beneficiari d\u2019un ajut CaixaImpulse, desenvolupa <\/span><b>un nou tractament per a l\u2019ELA que podria ser aplicable al 97\u00a0% dels pacients<\/b><span style=\"font-weight: 400;\">. \u00abEn aquest projecte, fet en col\u00b7laboraci\u00f3 amb la Universitat d\u2019Oxford, treballem amb un fragment d\u2019ARN missatger que corregeix una alteraci\u00f3 clau en un gen imprescindible perqu\u00e8 tingui lloc l\u2019autof\u00e0gia, un mecanisme de neteja\u00bb, explica el l\u00edder del projecte i investigador CaixaResearch. \u00abEl treball combina validaci\u00f3 precl\u00ednica, an\u00e0lisi de mercat i disseny d\u2019un primer assaig cl\u00ednic, i els seus resultats podrien obrir la porta a una nova ter\u00e0pia per a aquesta malaltia incurable.\u00bb<\/span><\/p>\n<div id=\"attachment_10534\" style=\"width: 410px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-10534\" class=\"wp-image-10534\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog11-300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog11-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog11-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog11-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog11-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog11-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><p id=\"caption-attachment-10534\" class=\"wp-caption-text\"><em>Manuel Portero<\/em><\/p><\/div>\n<p>&nbsp;<\/p>\n<h3><b><i>Un objectiu com\u00fa<\/i><\/b><\/h3>\n<p><span style=\"font-weight: 400;\">L\u2019inter\u00e8s cient\u00edfic per entendre i curar l\u2019ELA no ha deixat de cr\u00e9ixer els \u00faltims anys. I no \u00e9s casual: <\/span><b>la malaltia est\u00e0 deixant de ser una inc\u00f2gnita silenciada per convertir-se en una prioritat de la recerca biom\u00e8dica<\/b><span style=\"font-weight: 400;\">. Aix\u00ed ho demostra el treball dels investigadors i investigadores de la xarxa CaixaResearch i el comprom\u00eds d\u2019iniciatives com la Fundaci\u00f3n Luz\u00f3n, que estan ajudant a situar aquesta causa al centre de l\u2019agenda cient\u00edfica i social.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Avui, les seves veus ens recorden que, lluny de ser una batalla perduda, la recerca contra l\u2019ELA \u00e9s una cursa col\u00b7lectiva, un proc\u00e9s en qu\u00e8 cada aven\u00e7 compta i en qu\u00e8 investigadors, associacions i pacients s\u00f3n<\/span><b> peces clau per completar un puzle complex, per\u00f2 no impossible de resoldre<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-10591\" src=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-300x169.jpg\" alt=\"\" width=\"400\" height=\"225\" srcset=\"https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-300x169.jpg 300w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-1024x576.jpg 1024w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-768x432.jpg 768w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-1536x864.jpg 1536w, https:\/\/blog.caixaresearch.org\/wp-content\/uploads\/2025\/06\/DM-Ela-Blog-CATnologos-1-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/p>\n<p>Alguna cosa est\u00e0 canviant en la lluita contra l\u2019esclerosi lateral amiotr\u00f2fica (ELA).\u00a0<\/p>\n<p>Durant anys, aquesta malaltia neurodegenerativa ha estat sin\u00f2nim d\u2019incertesa, patiment i manca d\u2019opcions terap\u00e8utiques. Per\u00f2 en aquests \u00faltims temps, els aven\u00e7os cient\u00edfics estan dibuixant un nou horitz\u00f3: per primera vegada, <a href=\"https:\/\/www.labiotech.eu\/best-biotech\/als-companies\/\" target=\"_blank\" rel=\"noopener\">emergeixen ter\u00e0pies innovadores, <i>start-ups<\/i> especialitzades<\/a> i iniciatives que ofereixen resultats esperan\u00e7adors que podrien realment transformar el futur de l\u2019ELA.\u00a0<\/p>\n<p>Aquest impuls col\u00b7lectiu no neix tan sols de grans empreses o laboratoris, sin\u00f3 que tamb\u00e9 pren forma en universitats, hospitals i centres de recerca d\u2019arreu del m\u00f3n, on investigadors, metges i experts treballen dia rere dia amb un objectiu compartit: comprendre l\u2019ELA i acostar-se al seu tractament.\u00a0<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[520,519],"tags":[],"class_list":["post-10564","post","type-post","status-publish","format-standard","hentry","category-divulgacio-cientifica","category-investigacio"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00abJo tamb\u00e9 investigo per curar l\u2019ELA\u00bb - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/?p=10512\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00abJo tamb\u00e9 investigo per curar l\u2019ELA\u00bb - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Alguna cosa est\u00e0 canviant en la lluita contra l\u2019esclerosi lateral amiotr\u00f2fica (ELA).\u00a0 Durant anys, aquesta malaltia neurodegenerativa ha estat sin\u00f2nim d\u2019incertesa, patiment i manca d\u2019opcions terap\u00e8utiques. 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