{"id":10183,"date":"2025-04-28T08:52:53","date_gmt":"2025-04-28T07:52:53","guid":{"rendered":"https:\/\/blog.caixaresearch.org\/?p=10183"},"modified":"2025-04-29T08:33:10","modified_gmt":"2025-04-29T07:33:10","slug":"instantania-caixaresearch-una-recerca-caixaresearch-fa-un-pas-clau-cap-a-la-medicina-personalitzada-del-cancer-de-fetge","status":"publish","type":"post","link":"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-una-recerca-caixaresearch-fa-un-pas-clau-cap-a-la-medicina-personalitzada-del-cancer-de-fetge\/","title":{"rendered":"Instant\u00e0nia CaixaResearch: Una recerca CaixaResearch fa un pas clau cap a la medicina personalitzada del c\u00e0ncer de fetge"},"content":{"rendered":"

\"\"<\/p>\n

Cada any es diagnostiquen m\u00e9s de <\/b>860.000 casos nous de c\u00e0ncer de fetge<\/b><\/a> al m\u00f3n.<\/b> El carcinoma hepatocel\u00b7lular n\u2019\u00e9s el tipus m\u00e9s com\u00fa i una de les causes principals de mort per c\u00e0ncer. I \u00e9s que som davant d\u2019una malaltia especialment complexa, ja que es presenta en quatre subtipus diferents, cadascun amb alteracions gen\u00e8tiques i caracter\u00edstiques moleculars pr\u00f2pies.\u00a0<\/span><\/p>\n

Fins ara, la investigaci\u00f3 topava amb una gran dificultat: <\/span>la falta de models experimentals capa\u00e7os de reproduir fidelment aquesta complexitat<\/b>. Aquesta limitaci\u00f3 \u00e9s un fre important per al desenvolupament de nous tractaments, ja que impedeix de predir com respondran diferents pacients als f\u00e0rmacs i avan\u00e7ar d\u2019aquesta manera cap a ter\u00e0pies m\u00e9s personalitzades.\u00a0<\/span><\/p>\n

Ara, un nou estudi liderat pel doctor Josep M. Llovet, investigador del <\/span>Cl\u00ednic-IDIBAPS<\/span><\/a>, l\u00edder del Programa CaixaResearch de Recerca Translacional en C\u00e0ncer i catedr\u00e0tic de la Universitat de Barcelona, ofereix una soluci\u00f3 prometedora. En col\u00b7laboraci\u00f3 amb la University of Glasgow, <\/span>l\u2019equip CaixaResearch ha descrit 25 models de ratol\u00ed que reprodueixen amb gran precisi\u00f3 els 4 subtipus coneguts del carcinoma hepatocel\u00b7lular hum\u00e0<\/b>. En combinar aquests models amb organoides \u2014estructures que simulen \u00f2rgans en miniatura\u2014, els investigadors han aconseguit crear <\/span>una plataforma d\u2019alt rendiment capa\u00e7 d\u2019avaluar l\u2019efic\u00e0cia de diferents f\u00e0rmacs segons el subtipus tumoral<\/b>.\u00a0<\/span><\/p>\n

Els resultats, publicats a la prestigiosa revista <\/span>Nature<\/span><\/i><\/a>, tamb\u00e9 detallen el <\/span>primer gran assoliment de la plataforma per al cribratge de f\u00e0rmacs: la identificaci\u00f3 de la cladribina<\/b> com un tractament prometedor<\/b> en combinaci\u00f3 amb la ter\u00e0pia est\u00e0ndard.\u00a0<\/span><\/p>\n

\u00abAquest descobriment demostra el valor de la tecnologia per identificar noves estrat\u00e8gies terap\u00e8utiques i desenvolupar tractaments innovadors, m\u00e9s precisos i personalitzats, que representin una soluci\u00f3 efica\u00e7 per als pacients\u00bb, explica el doctor Llovet.\u00a0<\/span><\/p>\n

Vols compartir aquest aven\u00e7?<\/b> T\u2019expliquem tamb\u00e9 els detalls de l\u2019estudi en aquest fil de X<\/a>.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\"\"<\/p>\n

Cada any es diagnostiquen m\u00e9s de 860.000 casos nous de c\u00e0ncer de fetge<\/a> al m\u00f3n. El carcinoma hepatocel\u00b7lular n\u2019\u00e9s el tipus m\u00e9s com\u00fa i una de les causes principals de mort per c\u00e0ncer. I \u00e9s que som davant d\u2019una malaltia especialment complexa, ja que es presenta en quatre subtipus diferents, cadascun amb alteracions gen\u00e8tiques i caracter\u00edstiques moleculars pr\u00f2pies.\u00a0<\/p>\n

Fins ara, la investigaci\u00f3 topava amb una gran dificultat: la falta de models experimentals capa\u00e7os de reproduir fidelment aquesta complexitat. Aquesta limitaci\u00f3 \u00e9s un fre important per al desenvolupament de nous tractaments, ja que impedeix de predir com respondran diferents pacients als f\u00e0rmacs i avan\u00e7ar d\u2019aquesta manera cap a ter\u00e0pies m\u00e9s personalitzades.\u00a0<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[520,519],"tags":[],"class_list":["post-10183","post","type-post","status-publish","format-standard","hentry","category-divulgacio-cientifica","category-investigacio"],"acf":[],"yoast_head":"\nInstant\u00e0nia CaixaResearch: Una recerca CaixaResearch fa un pas clau cap a la medicina personalitzada del c\u00e0ncer de fetge - Blog CaixaCi\u00e8ncia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.caixaresearch.org\/ca\/instantania-caixaresearch-una-recerca-caixaresearch-fa-un-pas-clau-cap-a-la-medicina-personalitzada-del-cancer-de-fetge\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Instant\u00e0nia CaixaResearch: Una recerca CaixaResearch fa un pas clau cap a la medicina personalitzada del c\u00e0ncer de fetge - Blog CaixaCi\u00e8ncia\" \/>\n<meta property=\"og:description\" content=\"Cada any es diagnostiquen m\u00e9s de 860.000 casos nous de c\u00e0ncer de fetge al m\u00f3n. El carcinoma hepatocel\u00b7lular n\u2019\u00e9s el tipus m\u00e9s com\u00fa i una de les causes principals de mort per c\u00e0ncer. I \u00e9s que som davant d\u2019una malaltia especialment complexa, ja que es presenta en quatre subtipus diferents, cadascun amb alteracions gen\u00e8tiques i caracter\u00edstiques moleculars pr\u00f2pies.\u00a0 Fins ara, la investigaci\u00f3 topava amb una gran dificultat: la falta de models experimentals capa\u00e7os de reproduir fidelment aquesta complexitat. 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